DegronMD

Uniprot ID: Q8WXI7

Source protein: Mucin-16

Source gene: MUC16

Class: DEG_SCF_FBW7_2

Location: 5324:5330

E3 ligase: FBXW7

DEGRON score: 0.9744

ASA_SCORE: 97.7286

COIL: 0.9271

CONS_SCORE: 0

DSS_SCORE: 0.5464

HELIX: 0.0151

FCONS_SCORE: 0

RIG_SCORE: 0.7408

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G5315D	TCGA-AA-3510	COAD	TCGA	MTTPPVE	DEG_SCF_FBW7_2	0.0833
p.G5315D	DO7783	COAD	ICGC	MTTPPVE	DEG_SCF_FBW7_2	0.0833
p.P5318S	TCGA-D3-A8GR	SKCM	TCGA	MTTPPVE	DEG_SCF_FBW7_2	0.1667
p.P5318S	DO51247	SKCM	ICGC	MTTPPVE	DEG_SCF_FBW7_2	0.1667
p.P5327S	TCGA-EE-A3AE	SKCM	TCGA	MTTPPVE	DEG_SCF_FBW7_2	0.6752
p.P5327S	TCGA-FI-A2D5	UCEC	TCGA	MTTPPVE	DEG_SCF_FBW7_2	0.6752
p.P5327S	DO37802	SKCM	ICGC	MTTPPVE	DEG_SCF_FBW7_2	0.6752
p.P5327S	DO41331	UCEC	ICGC	MTTPPVE	DEG_SCF_FBW7_2	0.6752
p.S5337F	TCGA-FR-A8YC	SKCM	TCGA	MTTPPVE	DEG_SCF_FBW7_2	0.1389
p.S5337F	DO50301	SKCM	ICGC	MTTPPVE	DEG_SCF_FBW7_2	0.1389
p.S5336F	TCGA-IR-A3LA	CESC	TCGA	MTTPPVE	DEG_SCF_FBW7_2	0.1667
p.S5336F	DO44377	CESC	ICGC	MTTPPVE	DEG_SCF_FBW7_2	0.1667
p.S5334C	TCGA-LP-A4AV	CESC	TCGA	MTTPPVE	DEG_SCF_FBW7_2	0.2222
p.S5334C	DO44275	CESC	ICGC	MTTPPVE	DEG_SCF_FBW7_2	0.2222
p.S5334P	DO233154	GACA	ICGC	MTTPPVE	DEG_SCF_FBW7_2	0.2222
p.S5334P	SIDM00777	Colorectal Carcinoma	GDSC	MTTPPVE	DEG_SCF_FBW7_2	0.2222
p.S5334P	ACH-000360	Colon/Colorectal Cancer	CCLE	MTTPPVE	DEG_SCF_FBW7_2	0.2222
p.S5334P	NCI-H508	large_intestine	COSMIC	MTTPPVE	DEG_SCF_FBW7_2	0.2222
p.S5334F	DO27943	ORCA	ICGC	MTTPPVE	DEG_SCF_FBW7_2	0.2222
p.M5316I	DO32904	PACA	ICGC	MTTPPVE	DEG_SCF_FBW7_2	0.1111
p.V5329G	SIDM00336	Melanoma	GDSC	MTTPPVE	DEG_SCF_FBW7_2	0.6421
p.V5329G	ACH-000881	Skin Cancer	CCLE	MTTPPVE	DEG_SCF_FBW7_2	0.6421
p.V5329G	MEL-JUSO	skin	COSMIC	MTTPPVE	DEG_SCF_FBW7_2	0.6421

DegronMD: protein-targeted degradation, mutation and drug response to degrons