DegronMD

Uniprot ID: Q8WXI7

Source protein: Mucin-16

Source gene: MUC16

Class: DEG_SCF_FBW7_2

Location: 5620:5626

E3 ligase: FBXW7

DEGRON score: 0.8779

ASA_SCORE: 94.1429

COIL: 0.889

CONS_SCORE: 0

DSS_SCORE: 0.5977

HELIX: 0.019

FCONS_SCORE: 0

RIG_SCORE: 0.7242

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T5628S	TCGA-19-5956	GBM	TCGA	MTTPPVE	DEG_SCF_FBW7_2	0.2778
p.T5628S	TCGA-G4-6627	COAD	TCGA	MTTPPVE	DEG_SCF_FBW7_2	0.2778
p.T5628S	TCGA-P5-A5EV	LGG	TCGA	MTTPPVE	DEG_SCF_FBW7_2	0.2778
p.T5628S	DO9098	COAD	ICGC	MTTPPVE	DEG_SCF_FBW7_2	0.2778
p.T5628S	DO13863	GBM	ICGC	MTTPPVE	DEG_SCF_FBW7_2	0.2778
p.T5628S	DO50160	LGG	ICGC	MTTPPVE	DEG_SCF_FBW7_2	0.2778
p.P5623R	TCGA-66-2773	LUSC	TCGA	MTTPPVE	DEG_SCF_FBW7_2	0.7512
p.P5623R	DO26536	LUSC	ICGC	MTTPPVE	DEG_SCF_FBW7_2	0.7512
p.T5613I	TCGA-A7-A0CJ	BRCA	TCGA	MTTPPVE	DEG_SCF_FBW7_2	0.1389
p.T5613I	DO2874	BRCA	ICGC	MTTPPVE	DEG_SCF_FBW7_2	0.1389
p.R5610W	TCGA-AA-A00N	COAD	TCGA	MTTPPVE	DEG_SCF_FBW7_2	0.0556
p.R5610W	DO9876	COAD	ICGC	MTTPPVE	DEG_SCF_FBW7_2	0.0556
p.R5610W	DO220851	MELA	ICGC	MTTPPVE	DEG_SCF_FBW7_2	0.0556
p.D5616Y	TCGA-AP-A1DV	UCEC	TCGA	MTTPPVE	DEG_SCF_FBW7_2	0.2222
p.D5616Y	DO43186	UCEC	ICGC	MTTPPVE	DEG_SCF_FBW7_2	0.2222
p.R5612I	TCGA-AP-A1DV	UCEC	TCGA	MTTPPVE	DEG_SCF_FBW7_2	0.1111
p.R5612I	DO43186	UCEC	ICGC	MTTPPVE	DEG_SCF_FBW7_2	0.1111
p.D5616N	TCGA-D1-A103	UCEC	TCGA	MTTPPVE	DEG_SCF_FBW7_2	0.2222
p.D5616N	DO42312	UCEC	ICGC	MTTPPVE	DEG_SCF_FBW7_2	0.2222
p.L5634M	TCGA-D3-A3C1	SKCM	TCGA	MTTPPVE	DEG_SCF_FBW7_2	0.1111
p.L5634M	DO47323	SKCM	ICGC	MTTPPVE	DEG_SCF_FBW7_2	0.1111
p.S5633F	TCGA-D9-A6EC	SKCM	TCGA	MTTPPVE	DEG_SCF_FBW7_2	0.1389
p.S5633F	TCGA-EE-A2GR	SKCM	TCGA	MTTPPVE	DEG_SCF_FBW7_2	0.1389
p.S5633F	TCGA-QB-AA9O	SKCM	TCGA	MTTPPVE	DEG_SCF_FBW7_2	0.1389
p.S5633F	DO220852	MELA	ICGC	MTTPPVE	DEG_SCF_FBW7_2	0.1389
p.S5633F	DO222536	MELA	ICGC	MTTPPVE	DEG_SCF_FBW7_2	0.1389
p.S5633F	DO222753	MELA	ICGC	MTTPPVE	DEG_SCF_FBW7_2	0.1389
p.S5633F	DO50291	SKCM	ICGC	MTTPPVE	DEG_SCF_FBW7_2	0.1389
p.S5633F	DO37996	SKCM	ICGC	MTTPPVE	DEG_SCF_FBW7_2	0.1389
p.S5633F	DO51267	SKCM	ICGC	MTTPPVE	DEG_SCF_FBW7_2	0.1389
p.S5633F	SIDM01175	Other Sarcomas	GDSC	MTTPPVE	DEG_SCF_FBW7_2	0.1389
p.S5633F	SIDM00149	Melanoma	GDSC	MTTPPVE	DEG_SCF_FBW7_2	0.1389
p.S5633F	ACH-000750	Skin Cancer	CCLE	MTTPPVE	DEG_SCF_FBW7_2	0.1389
p.S5633F	ACH-002309	Sarcoma	CCLE	MTTPPVE	DEG_SCF_FBW7_2	0.1389
p.S5633F	SW684	soft_tissue	COSMIC	MTTPPVE	DEG_SCF_FBW7_2	0.1389
p.S5633F	LOXIMVI	skin	COSMIC	MTTPPVE	DEG_SCF_FBW7_2	0.1389
p.E5627K	TCGA-EE-A3AG	SKCM	TCGA	MTTPPVE	DEG_SCF_FBW7_2	0.3056
p.E5627K	DO37471	SKCM	ICGC	MTTPPVE	DEG_SCF_FBW7_2	0.3056
p.P5623L	TCGA-FS-A1ZP	SKCM	TCGA	MTTPPVE	DEG_SCF_FBW7_2	0.7582
p.P5623L	DO37703	SKCM	ICGC	MTTPPVE	DEG_SCF_FBW7_2	0.7582
p.T5622A	TCGA-NC-A5HI	LUSC	TCGA	MTTPPVE	DEG_SCF_FBW7_2	0.7139
p.T5622A	DO45461	LUSC	ICGC	MTTPPVE	DEG_SCF_FBW7_2	0.7139
p.R5610Q	DO48195	ESCA	ICGC	MTTPPVE	DEG_SCF_FBW7_2	0.0556
p.R5610Q	DO228933	LICA	ICGC	MTTPPVE	DEG_SCF_FBW7_2	0.0556
p.V5617A	DO23218	LINC	ICGC	MTTPPVE	DEG_SCF_FBW7_2	0.25
p.E5626D	DO23529	LIRI	ICGC	MTTPPVE	DEG_SCF_FBW7_2	0.6758
p.E5626K	DO222843	MELA	ICGC	MTTPPVE	DEG_SCF_FBW7_2	0.7022
p.E5626K	DO229456	SKCA	ICGC	MTTPPVE	DEG_SCF_FBW7_2	0.7022
p.T5613S	SIDM00625	Other Sarcomas	GDSC	MTTPPVE	DEG_SCF_FBW7_2	0.1389
p.T5613S	ACH-000449	Sarcoma	CCLE	MTTPPVE	DEG_SCF_FBW7_2	0.1389
p.T5613S	MES-SA	soft_tissue	COSMIC	MTTPPVE	DEG_SCF_FBW7_2	0.1389
p.T5628I	SIDM01175	Other Sarcomas	GDSC	MTTPPVE	DEG_SCF_FBW7_2	0.2778
p.T5628I	ACH-002309	Sarcoma	CCLE	MTTPPVE	DEG_SCF_FBW7_2	0.2778
p.T5628I	SW684	soft_tissue	COSMIC	MTTPPVE	DEG_SCF_FBW7_2	0.2778
p.S5611R	SIDM01071	Small Cell Lung Carcinoma	GDSC	MTTPPVE	DEG_SCF_FBW7_2	0.0833
p.S5611R	ACH-000515	Lung Cancer	CCLE	MTTPPVE	DEG_SCF_FBW7_2	0.0833
p.S5611R	HCC-33	lung	COSMIC	MTTPPVE	DEG_SCF_FBW7_2	0.0833
p.T5613A	SIDM00783	Colorectal Carcinoma	GDSC	MTTPPVE	DEG_SCF_FBW7_2	0.1389
p.T5613A	ACH-000971	Colon/Colorectal Cancer	CCLE	MTTPPVE	DEG_SCF_FBW7_2	0.1389
p.T5613A	HCT-116	large_intestine	COSMIC	MTTPPVE	DEG_SCF_FBW7_2	0.1389
p.P5624S	SIDM00167	Head and Neck Carcinoma	GDSC	MTTPPVE	DEG_SCF_FBW7_2	0.5641
p.P5624S	ACH-000715	Head and Neck Cancer	CCLE	MTTPPVE	DEG_SCF_FBW7_2	0.5641

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: MTTPPVE

Degron related mutations and impact score

Drug responses associated with MUC16 mutations

All proteins holding degron of MTTPPVE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WXI7	Mucin-16	DEG_SCF_FBW7_2	5324:5330	MTTPPVE	FBXW7	0.9744	More...
Q8WXI7	Mucin-16	DEG_SCF_FBW7_2	5620:5626	MTTPPVE	FBXW7	0.8779	More...