DegronMD

Uniprot ID: Q02817

Source protein: Mucin-2

Source gene: MUC2

Class: DEG_SCF_FBW7_1

Location: 1696:1702

E3 ligase: FBXW7

DEGRON score: 0.8345

ASA_SCORE: 102.6714

COIL: 0.9566

CONS_SCORE: 0.2961

DSS_SCORE: 0.762

HELIX: 0.0084

FCONS_SCORE: 0.9603

RIG_SCORE: 0.5833

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1690H	TCGA-PK-A5HB	ACC	TCGA	MTTPSPT	DEG_SCF_FBW7_1	0.1667
p.T1702S	DO6561	CLLE	ICGC	MTTPSPT	DEG_SCF_FBW7_1	0.6005
p.T1702S	DO224744	COCA	ICGC	MTTPSPT	DEG_SCF_FBW7_1	0.6005
p.T1702S	DO222778	COCA	ICGC	MTTPSPT	DEG_SCF_FBW7_1	0.6005
p.T1702S	DO222829	COCA	ICGC	MTTPSPT	DEG_SCF_FBW7_1	0.6005
p.T1702S	DO222842	COCA	ICGC	MTTPSPT	DEG_SCF_FBW7_1	0.6005
p.T1702S	DO51023	LAML	ICGC	MTTPSPT	DEG_SCF_FBW7_1	0.6005
p.T1702S	DO51008	LAML	ICGC	MTTPSPT	DEG_SCF_FBW7_1	0.6005
p.T1702S	DO229027	LICA	ICGC	MTTPSPT	DEG_SCF_FBW7_1	0.6005
p.T1702S	DO229053	LICA	ICGC	MTTPSPT	DEG_SCF_FBW7_1	0.6005
p.T1702S	DO68928	THCA	ICGC	MTTPSPT	DEG_SCF_FBW7_1	0.6005
p.S1698T	DO222741	COCA	ICGC	MTTPSPT	DEG_SCF_FBW7_1	0.7116
p.S1698T	DO228903	LICA	ICGC	MTTPSPT	DEG_SCF_FBW7_1	0.7116
p.S1698T	DO229053	LICA	ICGC	MTTPSPT	DEG_SCF_FBW7_1	0.7116
p.S1698T	DO229242	THCA	ICGC	MTTPSPT	DEG_SCF_FBW7_1	0.7116
p.S1698P	DO228908	LICA	ICGC	MTTPSPT	DEG_SCF_FBW7_1	0.6752
p.S1698P	DO228937	LICA	ICGC	MTTPSPT	DEG_SCF_FBW7_1	0.6752
p.S1698P	DO228974	LICA	ICGC	MTTPSPT	DEG_SCF_FBW7_1	0.6752
p.S1698P	DO228993	LICA	ICGC	MTTPSPT	DEG_SCF_FBW7_1	0.6752
p.S1698P	DO229040	LICA	ICGC	MTTPSPT	DEG_SCF_FBW7_1	0.6752
p.Q1707H	DO228916	LICA	ICGC	MTTPSPT	DEG_SCF_FBW7_1	0.1944
p.T1706M	DO232883	PBCA	ICGC	MTTPSPT	DEG_SCF_FBW7_1	0.2222
p.T1706M	DO232593	PBCA	ICGC	MTTPSPT	DEG_SCF_FBW7_1	0.2222
p.T1706M	DO71492	THCA	ICGC	MTTPSPT	DEG_SCF_FBW7_1	0.2222
p.P1690L	DO38187	STAD	ICGC	MTTPSPT	DEG_SCF_FBW7_1	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons