DegronMD

Uniprot ID: Q02817

Source protein: Mucin-2

Source gene: MUC2

Class: DEG_SCF_FBW7_1

Location: 1728:1734

E3 ligase: FBXW7

DEGRON score: 0.5628

ASA_SCORE: 100.5857

COIL: 0.956

CONS_SCORE: 0.2375

DSS_SCORE: 0.7981

HELIX: 0.0093

FCONS_SCORE: 0.8967

RIG_SCORE: 0.5554

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1723L	TCGA-BR-4187	STAD	TCGA	MTTPSPT	DEG_SCF_FBW7_1	0.1944
p.G1738D	TCGA-EY-A548	UCEC	TCGA	MTTPSPT	DEG_SCF_FBW7_1	0.2222
p.G1738D	DO48173	UCEC	ICGC	MTTPSPT	DEG_SCF_FBW7_1	0.2222
p.T1728S	DO6372	CLLE	ICGC	MTTPSPT	DEG_SCF_FBW7_1	0.7116
p.T1728S	DO228771	GACA	ICGC	MTTPSPT	DEG_SCF_FBW7_1	0.7116
p.T1728S	DO220906	MELA	ICGC	MTTPSPT	DEG_SCF_FBW7_1	0.7116
p.T1728S	DO51469	PACA	ICGC	MTTPSPT	DEG_SCF_FBW7_1	0.7116
p.T1728S	DO229268	THCA	ICGC	MTTPSPT	DEG_SCF_FBW7_1	0.7116
p.T1728S	DO229211	THCA	ICGC	MTTPSPT	DEG_SCF_FBW7_1	0.7116
p.P1721L	DO7124	CLLE	ICGC	MTTPSPT	DEG_SCF_FBW7_1	0.1389
p.P1721L	DO224701	COCA	ICGC	MTTPSPT	DEG_SCF_FBW7_1	0.1389
p.P1721L	DO224739	COCA	ICGC	MTTPSPT	DEG_SCF_FBW7_1	0.1389
p.P1721L	DO224744	COCA	ICGC	MTTPSPT	DEG_SCF_FBW7_1	0.1389
p.P1721L	DO222829	COCA	ICGC	MTTPSPT	DEG_SCF_FBW7_1	0.1389
p.P1721L	DO51020	LAML	ICGC	MTTPSPT	DEG_SCF_FBW7_1	0.1389
p.P1721L	DO229055	LICA	ICGC	MTTPSPT	DEG_SCF_FBW7_1	0.1389
p.P1721L	DO229062	LICA	ICGC	MTTPSPT	DEG_SCF_FBW7_1	0.1389
p.P1721L	DO229245	THCA	ICGC	MTTPSPT	DEG_SCF_FBW7_1	0.1389
p.P1724Q	DO230330	COCA	ICGC	MTTPSPT	DEG_SCF_FBW7_1	0.2222
p.P1721T	DO224689	COCA	ICGC	MTTPSPT	DEG_SCF_FBW7_1	0.1389
p.P1721T	DO222794	COCA	ICGC	MTTPSPT	DEG_SCF_FBW7_1	0.1389
p.P1721T	DO228945	LICA	ICGC	MTTPSPT	DEG_SCF_FBW7_1	0.1389
p.P1721T	DO229059	LICA	ICGC	MTTPSPT	DEG_SCF_FBW7_1	0.1389
p.G1738S	DO224620	COCA	ICGC	MTTPSPT	DEG_SCF_FBW7_1	0.2222
p.G1738S	DO50956	LICA	ICGC	MTTPSPT	DEG_SCF_FBW7_1	0.2222
p.G1738S	DO222532	MELA	ICGC	MTTPSPT	DEG_SCF_FBW7_1	0.2222
p.G1738S	DO229242	THCA	ICGC	MTTPSPT	DEG_SCF_FBW7_1	0.2222
p.T1744P	DO224766	COCA	ICGC	MTTPSPT	DEG_SCF_FBW7_1	0.0556
p.T1744P	DO224739	COCA	ICGC	MTTPSPT	DEG_SCF_FBW7_1	0.0556
p.T1744P	DO222888	COCA	ICGC	MTTPSPT	DEG_SCF_FBW7_1	0.0556
p.T1744P	DO225412	LAML	ICGC	MTTPSPT	DEG_SCF_FBW7_1	0.0556
p.T1744P	DO228950	LICA	ICGC	MTTPSPT	DEG_SCF_FBW7_1	0.0556
p.T1744P	DO228896	LICA	ICGC	MTTPSPT	DEG_SCF_FBW7_1	0.0556
p.T1744P	DO229046	LICA	ICGC	MTTPSPT	DEG_SCF_FBW7_1	0.0556
p.T1744P	DO229053	LICA	ICGC	MTTPSPT	DEG_SCF_FBW7_1	0.0556
p.T1744P	DO229140	THCA	ICGC	MTTPSPT	DEG_SCF_FBW7_1	0.0556
p.T1744P	DO229232	THCA	ICGC	MTTPSPT	DEG_SCF_FBW7_1	0.0556
p.S1725T	DO222829	COCA	ICGC	MTTPSPT	DEG_SCF_FBW7_1	0.25
p.S1725T	DO229053	LICA	ICGC	MTTPSPT	DEG_SCF_FBW7_1	0.25
p.S1725T	DO229055	LICA	ICGC	MTTPSPT	DEG_SCF_FBW7_1	0.25
p.S1725T	DO229061	LICA	ICGC	MTTPSPT	DEG_SCF_FBW7_1	0.25
p.S1725T	DO229006	LICA	ICGC	MTTPSPT	DEG_SCF_FBW7_1	0.25
p.P1732T	DO229003	COCA	ICGC	MTTPSPT	DEG_SCF_FBW7_1	0.7031
p.T1744S	DO233766	GACA	ICGC	MTTPSPT	DEG_SCF_FBW7_1	0.0556
p.T1744S	DO229061	LICA	ICGC	MTTPSPT	DEG_SCF_FBW7_1	0.0556
p.S1740T	DO228911	LICA	ICGC	MTTPSPT	DEG_SCF_FBW7_1	0.1667
p.T1728I	DO229058	LICA	ICGC	MTTPSPT	DEG_SCF_FBW7_1	0.7078
p.T1735A	DO37659	SKCM	ICGC	MTTPSPT	DEG_SCF_FBW7_1	0.3056
p.S1740N	DO38663	STAD	ICGC	MTTPSPT	DEG_SCF_FBW7_1	0.1667
p.K1742N	DO41458	UCEC	ICGC	MTTPSPT	DEG_SCF_FBW7_1	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: MTTPSPT

Degron related mutations and impact score

Drug responses associated with MUC2 mutations

All proteins holding degron of MTTPSPT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q02817	Mucin-2	DEG_SCF_FBW7_1	1696:1702	MTTPSPT	FBXW7	0.8345	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	1728:1734	MTTPSPT	FBXW7	0.5628	More...