DegronMD

Uniprot ID: Q14517

Source protein: Protocadherin Fat 1

Source gene: FAT1

Class: DEG_Kelch_Keap1_1

Location: 3073:3078

E3 ligase: KEAP1

DEGRON score: 0.6013

ASA_SCORE: 51.0667

COIL: 0.7935

CONS_SCORE: 0.4536

DSS_SCORE: 0.5073

HELIX: 0.0162

FCONS_SCORE: 0.7852

RIG_SCORE: 0.7003

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D3075Y	TCGA-19-5956	GBM	TCGA	NPDTGE	DEG_Kelch_Keap1_1	0.7325
p.D3075Y	DO13863	GBM	ICGC	NPDTGE	DEG_Kelch_Keap1_1	0.7325
p.A3067T	TCGA-A5-A0G2	UCEC	TCGA	NPDTGE	DEG_Kelch_Keap1_1	0.1667
p.A3067T	DO41235	UCEC	ICGC	NPDTGE	DEG_Kelch_Keap1_1	0.1667
p.L3072P	TCGA-AY-6197	COAD	TCGA	NPDTGE	DEG_Kelch_Keap1_1	0.3056
p.L3072P	DO9956	COAD	ICGC	NPDTGE	DEG_Kelch_Keap1_1	0.3056
p.G3077C	TCGA-SL-A6JA	UCEC	TCGA	NPDTGE	DEG_Kelch_Keap1_1	0.76
p.G3077C	DO219787	UCEC	ICGC	NPDTGE	DEG_Kelch_Keap1_1	0.76
p.R3087C	DO222731	MELA	ICGC	NPDTGE	DEG_Kelch_Keap1_1	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons