DegronMD

Uniprot ID: Q9UN75

Source protein: Protocadherin alpha-12

Source gene: PCDHA12

Class: DEG_Kelch_Keap1_1

Location: 296:301

E3 ligase: KEAP1

DEGRON score: 0.5991

ASA_SCORE: 63.8667

COIL: 0.8323

CONS_SCORE: 0.6306

DSS_SCORE: 0.2085

HELIX: 0.022

FCONS_SCORE: 1.1999

RIG_SCORE: 0.8003

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P297A	DO50897	LICA	ICGC	NPDTGE	DEG_Kelch_Keap1_1	0.6392
p.D309N	DO220873	MELA	ICGC	NPDTGE	DEG_Kelch_Keap1_1	0.1111
p.E311K	SIDM00842	Colorectal Carcinoma	GDSC	NPDTGE	DEG_Kelch_Keap1_1	0.0556
p.E311K	ACH-000202	Colon/Colorectal Cancer	CCLE	NPDTGE	DEG_Kelch_Keap1_1	0.0556
p.E311K	COLO-320-HSR	large_intestine	COSMIC	NPDTGE	DEG_Kelch_Keap1_1	0.0556
p.G300S	SIDM00327	Hodgkin's Lymphoma	GDSC	NPDTGE	DEG_Kelch_Keap1_1	0.6993
p.G300S	ACH-000754	Lymphoma	CCLE	NPDTGE	DEG_Kelch_Keap1_1	0.6993
p.G300S	L-428	haematopoietic_and_lymphoid_tissue	COSMIC	NPDTGE	DEG_Kelch_Keap1_1	0.6993
p.C291S	ACH-000612	Lymphoma	CCLE	NPDTGE	DEG_Kelch_Keap1_1	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons