DegronMD

Uniprot ID: Q6W4X9

Source protein: Mucin-6

Source gene: MUC6

Class: DEG_SCF_FBW7_1

Location: 1535:1542

E3 ligase: FBXW7

DEGRON score: 0.9794

ASA_SCORE: 102.4875

COIL: 0.9328

CONS_SCORE: 0.1891

DSS_SCORE: 0.7346

HELIX: 0.0121

FCONS_SCORE: 1.024

RIG_SCORE: 0.6128

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T1529N	TCGA-EE-A2M5	SKCM	TCGA	PEVTPTST	DEG_SCF_FBW7_1	0.1667
p.T1529N	DO222423	MELA	ICGC	PEVTPTST	DEG_SCF_FBW7_1	0.1667
p.T1529N	DO37425	SKCM	ICGC	PEVTPTST	DEG_SCF_FBW7_1	0.1667
p.P1539T	DO224735	COCA	ICGC	PEVTPTST	DEG_SCF_FBW7_1	0.7031
p.P1539T	DO229010	COCA	ICGC	PEVTPTST	DEG_SCF_FBW7_1	0.7031
p.P1539T	DO229013	COCA	ICGC	PEVTPTST	DEG_SCF_FBW7_1	0.7031
p.P1539T	DO229016	COCA	ICGC	PEVTPTST	DEG_SCF_FBW7_1	0.7031
p.P1539T	DO229003	COCA	ICGC	PEVTPTST	DEG_SCF_FBW7_1	0.7031
p.P1539T	DO229005	COCA	ICGC	PEVTPTST	DEG_SCF_FBW7_1	0.7031
p.T1540N	DO224735	COCA	ICGC	PEVTPTST	DEG_SCF_FBW7_1	0.5944
p.T1540N	DO224757	COCA	ICGC	PEVTPTST	DEG_SCF_FBW7_1	0.5944
p.T1540N	DO229010	COCA	ICGC	PEVTPTST	DEG_SCF_FBW7_1	0.5944
p.T1540N	DO229013	COCA	ICGC	PEVTPTST	DEG_SCF_FBW7_1	0.5944
p.T1540N	DO229016	COCA	ICGC	PEVTPTST	DEG_SCF_FBW7_1	0.5944
p.T1540N	DO229003	COCA	ICGC	PEVTPTST	DEG_SCF_FBW7_1	0.5944
p.T1540N	DO229005	COCA	ICGC	PEVTPTST	DEG_SCF_FBW7_1	0.5944
p.T1544M	DO222765	COCA	ICGC	PEVTPTST	DEG_SCF_FBW7_1	0.2778
p.V1537I	DO229010	COCA	ICGC	PEVTPTST	DEG_SCF_FBW7_1	0.5965
p.V1537I	DO229013	COCA	ICGC	PEVTPTST	DEG_SCF_FBW7_1	0.5965
p.V1537I	DO229016	COCA	ICGC	PEVTPTST	DEG_SCF_FBW7_1	0.5965
p.V1537I	DO229003	COCA	ICGC	PEVTPTST	DEG_SCF_FBW7_1	0.5965
p.V1537I	DO229005	COCA	ICGC	PEVTPTST	DEG_SCF_FBW7_1	0.5965
p.H1528P	DO229010	COCA	ICGC	PEVTPTST	DEG_SCF_FBW7_1	0.1389
p.H1528P	DO229013	COCA	ICGC	PEVTPTST	DEG_SCF_FBW7_1	0.1389
p.H1528P	DO229016	COCA	ICGC	PEVTPTST	DEG_SCF_FBW7_1	0.1389
p.H1528P	DO229003	COCA	ICGC	PEVTPTST	DEG_SCF_FBW7_1	0.1389
p.H1528P	DO229005	COCA	ICGC	PEVTPTST	DEG_SCF_FBW7_1	0.1389
p.S1551R	DO233941	GACA	ICGC	PEVTPTST	DEG_SCF_FBW7_1	0.0833
p.E1536K	DO220903	MELA	ICGC	PEVTPTST	DEG_SCF_FBW7_1	0.591

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6W4X9	Mucin-6	DEG_SCF_FBW7_1	1535:1542	PEVTPTST	FBXW7	0.9794	More...
Q6W4X9	Mucin-6	DEG_SCF_FBW7_1	1928:1935	PEVTPTST	FBXW7	0.8659	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PEVTPTST

Degron related mutations and impact score

Drug responses associated with MUC6 mutations

All proteins holding degron of PEVTPTST