DegronMD

Uniprot ID: Q6W4X9

Source protein: Mucin-6

Source gene: MUC6

Class: DEG_SCF_FBW7_1

Location: 1928:1935

E3 ligase: FBXW7

DEGRON score: 0.8659

ASA_SCORE: 97.35

COIL: 0.9079

CONS_SCORE: 0.3136

DSS_SCORE: 0.6872

HELIX: 0.0161

FCONS_SCORE: 1.0922

RIG_SCORE: 0.6333

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Y1920S	DO48395	BLCA	ICGC	PEVTPTST	DEG_SCF_FBW7_1	0.1111
p.Y1920S	DO48385	BLCA	ICGC	PEVTPTST	DEG_SCF_FBW7_1	0.1111
p.Y1920S	DO48390	BLCA	ICGC	PEVTPTST	DEG_SCF_FBW7_1	0.1111
p.Y1920S	DO48377	BLCA	ICGC	PEVTPTST	DEG_SCF_FBW7_1	0.1111
p.Y1920S	DO48370	BLCA	ICGC	PEVTPTST	DEG_SCF_FBW7_1	0.1111
p.Y1920S	DO48432	BLCA	ICGC	PEVTPTST	DEG_SCF_FBW7_1	0.1111
p.T1922I	DO224817	COCA	ICGC	PEVTPTST	DEG_SCF_FBW7_1	0.1667
p.T1922I	DO222800	COCA	ICGC	PEVTPTST	DEG_SCF_FBW7_1	0.1667
p.H1942P	DO229010	COCA	ICGC	PEVTPTST	DEG_SCF_FBW7_1	0.1389
p.H1942P	DO229013	COCA	ICGC	PEVTPTST	DEG_SCF_FBW7_1	0.1389
p.H1942P	DO229016	COCA	ICGC	PEVTPTST	DEG_SCF_FBW7_1	0.1389
p.H1942P	DO229003	COCA	ICGC	PEVTPTST	DEG_SCF_FBW7_1	0.1389
p.H1942P	DO229005	COCA	ICGC	PEVTPTST	DEG_SCF_FBW7_1	0.1389
p.N1937T	DO229010	COCA	ICGC	PEVTPTST	DEG_SCF_FBW7_1	0.2778
p.N1937T	DO229013	COCA	ICGC	PEVTPTST	DEG_SCF_FBW7_1	0.2778
p.N1937T	DO229003	COCA	ICGC	PEVTPTST	DEG_SCF_FBW7_1	0.2778
p.N1937T	DO229268	THCA	ICGC	PEVTPTST	DEG_SCF_FBW7_1	0.2778
p.P1919H	DO229010	COCA	ICGC	PEVTPTST	DEG_SCF_FBW7_1	0.0833
p.P1919H	DO229013	COCA	ICGC	PEVTPTST	DEG_SCF_FBW7_1	0.0833
p.P1919H	DO229016	COCA	ICGC	PEVTPTST	DEG_SCF_FBW7_1	0.0833
p.P1919H	DO229003	COCA	ICGC	PEVTPTST	DEG_SCF_FBW7_1	0.0833
p.P1919H	DO229005	COCA	ICGC	PEVTPTST	DEG_SCF_FBW7_1	0.0833
p.P1919H	DO52379	LUSC	ICGC	PEVTPTST	DEG_SCF_FBW7_1	0.0833
p.P1919H	DO52345	LUSC	ICGC	PEVTPTST	DEG_SCF_FBW7_1	0.0833
p.P1919H	DO52388	LUSC	ICGC	PEVTPTST	DEG_SCF_FBW7_1	0.0833
p.P1919H	DO52383	LUSC	ICGC	PEVTPTST	DEG_SCF_FBW7_1	0.0833
p.K1941N	DO229010	COCA	ICGC	PEVTPTST	DEG_SCF_FBW7_1	0.2778
p.K1941N	DO229013	COCA	ICGC	PEVTPTST	DEG_SCF_FBW7_1	0.2778
p.K1941N	DO229003	COCA	ICGC	PEVTPTST	DEG_SCF_FBW7_1	0.2778
p.L1918I	SIDM00789	Colorectal Carcinoma	GDSC	PEVTPTST	DEG_SCF_FBW7_1	0.0556
p.L1918I	HCT-15	large_intestine	COSMIC	PEVTPTST	DEG_SCF_FBW7_1	0.0556
p.S1934Y	SIDM00475	Ovarian Carcinoma	GDSC	PEVTPTST	DEG_SCF_FBW7_1	0.6009
p.S1934Y	ACH-000091	Ovarian Cancer	CCLE	PEVTPTST	DEG_SCF_FBW7_1	0.6009
p.S1934Y	OV-56	ovary	COSMIC	PEVTPTST	DEG_SCF_FBW7_1	0.6009
p.T1945K	SIDM00121	T-Lymphoblastic Leukemia	GDSC	PEVTPTST	DEG_SCF_FBW7_1	0.0556
p.T1945K	CCRF-CEM	haematopoietic_and_lymphoid_tissue	COSMIC	PEVTPTST	DEG_SCF_FBW7_1	0.0556
p.E1929A	EW-18	bone	COSMIC	PEVTPTST	DEG_SCF_FBW7_1	0.659
p.E1929A	ML-1	thyroid	COSMIC	PEVTPTST	DEG_SCF_FBW7_1	0.659
p.E1929A	BxPC-3	pancreas	COSMIC	PEVTPTST	DEG_SCF_FBW7_1	0.659
p.E1929A	CAPAN-1	pancreas	COSMIC	PEVTPTST	DEG_SCF_FBW7_1	0.659
p.E1929A	ETK-1	biliary_tract	COSMIC	PEVTPTST	DEG_SCF_FBW7_1	0.659

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PEVTPTST

Degron related mutations and impact score

Drug responses associated with MUC6 mutations

All proteins holding degron of PEVTPTST

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6W4X9	Mucin-6	DEG_SCF_FBW7_1	1535:1542	PEVTPTST	FBXW7	0.9794	More...
Q6W4X9	Mucin-6	DEG_SCF_FBW7_1	1928:1935	PEVTPTST	FBXW7	0.8659	More...