DegronMD

Uniprot ID: O95298

Source protein: NADH dehydrogenase [ubiquinone] 1 subunit C2

Source gene: NDUFC2

Class: DEG_APCC_TPR_1

Location: 117:119

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8991

ASA_SCORE: 102.2667

COIL: 0.816

CONS_SCORE: 0.873

DSS_SCORE: 0.805

HELIX: 0.0213

FCONS_SCORE: 1.268

RIG_SCORE: 0.8029

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R119L	TCGA-55-8089	LUAD	TCGA	PIR	DEG_APCC_TPR_1	0.8428
p.R119C	TCGA-AJ-A3OJ	UCEC	TCGA	PIR	DEG_APCC_TPR_1	0.8301
p.H116Y	TCGA-W3-A825	SKCM	TCGA	PIR	DEG_APCC_TPR_1	0.3056
p.F115S	SIDM00779	Colorectal Carcinoma	GDSC	PIR	DEG_APCC_TPR_1	0.2778
p.H116L	ACH-001791	Liposarcoma	CCLE	PIR	DEG_APCC_TPR_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95298	NADH dehydrogenase [ubiquinone] 1 subunit C2	DEG_APCC_TPR_1	117:119	PIR	APC,CDC20,FZR1	0.8991	More...
Q96N11	Integrator complex subunit 15	DEG_APCC_TPR_1	447:449	PIR	APC,CDC20,FZR1	0.9974	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons