DegronMD

Uniprot ID: Q96N11

Source protein: Integrator complex subunit 15

Source gene: INTS15

Class: DEG_APCC_TPR_1

Location: 447:449

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9974

ASA_SCORE: 125.5

COIL: 0.948

CONS_SCORE: 0.3024

DSS_SCORE: 0.7761

HELIX: 0.0223

FCONS_SCORE: 1.0866

RIG_SCORE: 0.7932

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R449H	TCGA-FI-A2D0	UCEC	TCGA	PIR	DEG_APCC_TPR_1	0.8244
p.R449H	DO43891	UCEC	ICGC	PIR	DEG_APCC_TPR_1	0.8244
p.R449H	DO42673	UCEC	ICGC	PIR	DEG_APCC_TPR_1	0.8244

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95298	NADH dehydrogenase [ubiquinone] 1 subunit C2	DEG_APCC_TPR_1	117:119	PIR	APC,CDC20,FZR1	0.8991	More...
Q96N11	Integrator complex subunit 15	DEG_APCC_TPR_1	447:449	PIR	APC,CDC20,FZR1	0.9974	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons