DegronMD

Uniprot ID: Q6P6B1

Source protein: Glutamate-rich protein 5

Source gene: ERICH5

Class: DEG_APCC_KENBOX_2

Location: 262:266

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9346

ASA_SCORE: 113.48

COIL: 0.9286

CONS_SCORE: 0.6945

DSS_SCORE: 0.5588

HELIX: 0.0346

FCONS_SCORE: 0.9893

RIG_SCORE: 0.7033

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D272H	SIDM00745	Non-Small Cell Lung Carcinoma	GDSC	PKENV	DEG_APCC_KENBOX_2	0.1667
p.D272H	NCI-H1650	lung	COSMIC	PKENV	DEG_APCC_KENBOX_2	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94913	Pre-mRNA cleavage complex 2 protein Pcf11	DEG_APCC_KENBOX_2	581:585	PKENV	APC,CDC20,FZR1	0.9628	More...
Q6P6B1	Glutamate-rich protein 5	DEG_APCC_KENBOX_2	262:266	PKENV	APC,CDC20,FZR1	0.9346	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons