DegronMD

Uniprot ID: Q9HC84

Source protein: Mucin-5B

Source gene: MUC5B

Class: DEG_SCF_FBW7_1

Location: 3096:3103

E3 ligase: FBXW7

DEGRON score: 0.692

ASA_SCORE: 95.3

COIL: 0.922

CONS_SCORE: 0.2357

DSS_SCORE: 0.6673

HELIX: 0.0215

FCONS_SCORE: 1.0295

RIG_SCORE: 0.6174

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P3100T	TCGA-22-5492	LUSC	TCGA	PSSTPETT	DEG_SCF_FBW7_1	0.7031
p.P3100Q	TCGA-EE-A29G	SKCM	TCGA	PSSTPETT	DEG_SCF_FBW7_1	0.7035
p.A3092T	DO230309	COCA	ICGC	PSSTPETT	DEG_SCF_FBW7_1	0.2222
p.E3104Q	DO48228	ESCA	ICGC	PSSTPETT	DEG_SCF_FBW7_1	0.3056
p.P3103T	DO27208	LUSC	ICGC	PSSTPETT	DEG_SCF_FBW7_1	0.7031
p.P3103Q	DO47303	SKCM	ICGC	PSSTPETT	DEG_SCF_FBW7_1	0.7035
p.A3089T	SIDM00334	Endometrial Carcinoma	GDSC	PSSTPETT	DEG_SCF_FBW7_1	0.1389
p.A3089T	SIDM00661	B-Cell Non-Hodgkin's Lymphoma	GDSC	PSSTPETT	DEG_SCF_FBW7_1	0.1389
p.A3089T	ACH-000879	Endometrial/Uterine Cancer	CCLE	PSSTPETT	DEG_SCF_FBW7_1	0.1389
p.A3089T	ACH-000914	Lymphoma	CCLE	PSSTPETT	DEG_SCF_FBW7_1	0.1389
p.A3089T	MFE-296	endometrium	COSMIC	PSSTPETT	DEG_SCF_FBW7_1	0.1389
p.A3089T	HT	haematopoietic_and_lymphoid_tissue	COSMIC	PSSTPETT	DEG_SCF_FBW7_1	0.1389
p.I3094V	SIDM00333	Endometrial Carcinoma	GDSC	PSSTPETT	DEG_SCF_FBW7_1	0.2778
p.I3094V	ACH-000988	Endometrial/Uterine Cancer	CCLE	PSSTPETT	DEG_SCF_FBW7_1	0.2778
p.I3094V	MFE-319	endometrium	COSMIC	PSSTPETT	DEG_SCF_FBW7_1	0.2778
p.T3111M	SIDM00488	Colorectal Carcinoma	GDSC	PSSTPETT	DEG_SCF_FBW7_1	0.1111
p.T3111M	ACH-002345	Colon/Colorectal Cancer	CCLE	PSSTPETT	DEG_SCF_FBW7_1	0.1111
p.T3111M	CaR-1	large_intestine	COSMIC	PSSTPETT	DEG_SCF_FBW7_1	0.1111
p.E3101D	SIDM00903	Non-Small Cell Lung Carcinoma	GDSC	PSSTPETT	DEG_SCF_FBW7_1	0.5647
p.E3101D	ACH-000681	Lung Cancer	CCLE	PSSTPETT	DEG_SCF_FBW7_1	0.5647
p.E3101D	A549	lung	COSMIC	PSSTPETT	DEG_SCF_FBW7_1	0.5647
p.T3102S	NCI-H835	lung	COSMIC	PSSTPETT	DEG_SCF_FBW7_1	0.6005

DegronMD: protein-targeted degradation, mutation and drug response to degrons