DegronMD

Uniprot ID: Q9HC84

Source protein: Mucin-5B

Source gene: MUC5B

Class: DEG_SCF_FBW7_1

Location: 4353:4360

E3 ligase: FBXW7

DEGRON score: 0.9703

ASA_SCORE: 94.725

COIL: 0.9111

CONS_SCORE: -1000

DSS_SCORE: 0.6568

HELIX: 0.0246

FCONS_SCORE: 1.2223

RIG_SCORE: 0.6258

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S4355C	TCGA-66-2744	LUSC	TCGA	PSSTPETT	DEG_SCF_FBW7_1	0.643
p.V4365L	TCGA-98-A538	LUSC	TCGA	PSSTPETT	DEG_SCF_FBW7_1	0.1944
p.V4345A	TCGA-AX-A3FT	UCEC	TCGA	PSSTPETT	DEG_SCF_FBW7_1	0.1111
p.T4368M	TCGA-CN-6021	HNSC	TCGA	PSSTPETT	DEG_SCF_FBW7_1	0.1111
p.T4368M	SIDM00499	Prostate Carcinoma	GDSC	PSSTPETT	DEG_SCF_FBW7_1	0.1111
p.T4368M	22RV1	prostate	COSMIC	PSSTPETT	DEG_SCF_FBW7_1	0.1111
p.A4346T	TCGA-DB-A64X	LGG	TCGA	PSSTPETT	DEG_SCF_FBW7_1	0.1389
p.I4351M	TCGA-DG-A2KK	CESC	TCGA	PSSTPETT	DEG_SCF_FBW7_1	0.2778
p.S4349C	TCGA-DI-A1BU	UCEC	TCGA	PSSTPETT	DEG_SCF_FBW7_1	0.6667
p.P4344L	TCGA-EB-A5UM	SKCM	TCGA	PSSTPETT	DEG_SCF_FBW7_1	0.0833
p.P4344L	TCGA-WE-A8K5	SKCM	TCGA	PSSTPETT	DEG_SCF_FBW7_1	0.0833
p.T4368K	TCGA-EL-A3ZR	THCA	TCGA	PSSTPETT	DEG_SCF_FBW7_1	0.1111
p.P4353S	TCGA-ER-A193	SKCM	TCGA	PSSTPETT	DEG_SCF_FBW7_1	0.6752
p.P4344H	TCGA-HU-A4H3	STAD	TCGA	PSSTPETT	DEG_SCF_FBW7_1	0.0833
p.T4344I	DO5905	BRCA	ICGC	PSSTPETT	DEG_SCF_FBW7_1	0.0833
p.I4354M	DO51595	CESC	ICGC	PSSTPETT	DEG_SCF_FBW7_1	0.7618
p.S4357T	DO233705	GACA	ICGC	PSSTPETT	DEG_SCF_FBW7_1	0.7116
p.V4348M	DO51032	LAML	ICGC	PSSTPETT	DEG_SCF_FBW7_1	0.1944
p.V4348M	DO229033	LICA	ICGC	PSSTPETT	DEG_SCF_FBW7_1	0.1944
p.V4348M	DO229211	THCA	ICGC	PSSTPETT	DEG_SCF_FBW7_1	0.1944
p.A4349T	DO44570	LGG	ICGC	PSSTPETT	DEG_SCF_FBW7_1	0.6667
p.V4368L	DO219177	LUSC	ICGC	PSSTPETT	DEG_SCF_FBW7_1	0.1111
p.S4358C	DO27025	LUSC	ICGC	PSSTPETT	DEG_SCF_FBW7_1	0.7541
p.P4360L	DO224705	PACA	ICGC	PSSTPETT	DEG_SCF_FBW7_1	0.7582
p.T4359I	DO35553	PBCA	ICGC	PSSTPETT	DEG_SCF_FBW7_1	0.5966
p.P4347L	DO47282	SKCM	ICGC	PSSTPETT	DEG_SCF_FBW7_1	0.6111
p.P4347L	DO51282	SKCM	ICGC	PSSTPETT	DEG_SCF_FBW7_1	0.6111
p.P4356S	DO47368	SKCM	ICGC	PSSTPETT	DEG_SCF_FBW7_1	0.6752
p.P4347H	DO47903	STAD	ICGC	PSSTPETT	DEG_SCF_FBW7_1	0.6111
p.V4348A	DO40801	UCEC	ICGC	PSSTPETT	DEG_SCF_FBW7_1	0.1944
p.S4352C	DO42023	UCEC	ICGC	PSSTPETT	DEG_SCF_FBW7_1	0.3056
p.A4370T	SIDM00072	Non-Cancerous	GDSC	PSSTPETT	DEG_SCF_FBW7_1	0.0556
p.A4370T	SIDM00013	Melanoma	GDSC	PSSTPETT	DEG_SCF_FBW7_1	0.0556
p.A4370T	SIDM00049	Colorectal Carcinoma	GDSC	PSSTPETT	DEG_SCF_FBW7_1	0.0556
p.V4345M	SIDM00293	Small Cell Lung Carcinoma	GDSC	PSSTPETT	DEG_SCF_FBW7_1	0.1111
p.V4345M	OSC-20	upper_aerodigestive_tract	COSMIC	PSSTPETT	DEG_SCF_FBW7_1	0.1111
p.V4345M	LU-139	lung	COSMIC	PSSTPETT	DEG_SCF_FBW7_1	0.1111
p.T4359S	SIDM00793	Burkitt's Lymphoma	GDSC	PSSTPETT	DEG_SCF_FBW7_1	0.6005
p.T4359S	SIDM01133	Other Solid Cancers	GDSC	PSSTPETT	DEG_SCF_FBW7_1	0.6005
p.T4359S	NCI-H835	lung	COSMIC	PSSTPETT	DEG_SCF_FBW7_1	0.6005
p.T4359S	EB-3	haematopoietic_and_lymphoid_tissue	COSMIC	PSSTPETT	DEG_SCF_FBW7_1	0.6005
p.P4344S	SIDM00951	T-Lymphoblastic Leukemia	GDSC	PSSTPETT	DEG_SCF_FBW7_1	0.0833
p.P4344S	ACH-002222	Leukemia	CCLE	PSSTPETT	DEG_SCF_FBW7_1	0.0833
p.P4344S	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	PSSTPETT	DEG_SCF_FBW7_1	0.0833
p.T4347A	SIDM01450	Gastric Carcinoma	GDSC	PSSTPETT	DEG_SCF_FBW7_1	0.6111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PSSTPETT

Degron related mutations and impact score

Drug responses associated with MUC5B mutations

All proteins holding degron of PSSTPETT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9HC84	Mucin-5B	DEG_SCF_FBW7_1	3096:3103	PSSTPETT	FBXW7	0.692	More...
Q9HC84	Mucin-5B	DEG_SCF_FBW7_1	4353:4360	PSSTPETT	FBXW7	0.9703	More...