DegronMD

Uniprot ID: P41236

Source protein: Protein phosphatase inhibitor 2

Source gene: PPP1R2

Class: DEG_SCF_FBW7_1

Location: 71:77

E3 ligase: FBXW7

DEGRON score: 0.9989

ASA_SCORE: 63.7286

COIL: 0.79

CONS_SCORE: 0.6653

DSS_SCORE: 0.5305

HELIX: 0.1126

FCONS_SCORE: 1.0634

RIG_SCORE: 0.6685

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E70K	TCGA-77-8136	LUSC	TCGA	PSTPYHS	DEG_SCF_FBW7_1	0.3056
p.E70K	DO26593	LUSC	ICGC	PSTPYHS	DEG_SCF_FBW7_1	0.3056
p.A85V	TCGA-AD-5900	COAD	TCGA	PSTPYHS	DEG_SCF_FBW7_1	0.1111
p.A85V	DO8514	COAD	ICGC	PSTPYHS	DEG_SCF_FBW7_1	0.1111
p.A85T	DO223048	ESCA	ICGC	PSTPYHS	DEG_SCF_FBW7_1	0.1111
p.D69G	DO44875	LIHC	ICGC	PSTPYHS	DEG_SCF_FBW7_1	0.2778
p.M79T	SIDM00264	Ewing's Sarcoma	GDSC	PSTPYHS	DEG_SCF_FBW7_1	0.2778
p.M79T	ACH-002105	Bone Cancer	CCLE	PSTPYHS	DEG_SCF_FBW7_1	0.2778
p.M79T	ES4	bone	COSMIC	PSTPYHS	DEG_SCF_FBW7_1	0.2778
p.M78I	ACH-000961	Endometrial/Uterine Cancer	CCLE	PSTPYHS	DEG_SCF_FBW7_1	0.3056
p.A85S	ACH-001510	Head and Neck Cancer	CCLE	PSTPYHS	DEG_SCF_FBW7_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P41236	Protein phosphatase inhibitor 2	DEG_SCF_FBW7_1	71:77	PSTPYHS	FBXW7	0.9989	More...
Q96PQ5	Putative protein phosphatase inhibitor 2-like protein 1	DEG_SCF_FBW7_1	71:77	PSTPYHS	FBXW7	0.9865	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons