DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
PSTPYHS
Uniprot ID:
Q96PQ5
Source protein:
Putative protein phosphatase inhibitor 2-like protein 1
Source gene:
PPP1R2P1
Class:
DEG_SCF_FBW7_1
Location:
71:77
E3 ligase:
FBXW7
DEGRON score:
0.9865
ASA_SCORE:
65.1714
COIL:
0.8599
CONS_SCORE:
0.7373
DSS_SCORE:
0.5659
HELIX:
0.0747
FCONS_SCORE:
1.0949
RIG_SCORE:
0.6534
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with PPP1R2P1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PSTPYHS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P41236
Protein phosphatase inhibitor 2
DEG_SCF_FBW7_1
71:77
PSTPYHS
FBXW7
0.9989
More...
Q96PQ5
Putative protein phosphatase inhibitor 2-like protein 1
DEG_SCF_FBW7_1
71:77
PSTPYHS
FBXW7
0.9865
More...