DegronMD

Uniprot ID: Q9HC84

Source protein: Mucin-5B

Source gene: MUC5B

Class: DEG_SCF_FBW7_1

Location: 3150:3157

E3 ligase: FBXW7

DEGRON score: 0.9919

ASA_SCORE: 89.1625

COIL: 0.9365

CONS_SCORE: -1000

DSS_SCORE: 0.6431

HELIX: 0.0146

FCONS_SCORE: 1.3751

RIG_SCORE: 0.668

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A3147G	TCGA-86-8279	LUAD	TCGA	PTATPSST	DEG_SCF_FBW7_1	0.25
p.A3147G	SIDM00313	Hodgkin's Lymphoma	GDSC	PTATPSST	DEG_SCF_FBW7_1	0.25
p.A3147G	SIDM01058	B-Cell Non-Hodgkin's Lymphoma	GDSC	PTATPSST	DEG_SCF_FBW7_1	0.25
p.A3147G	SIDM00756	Non-Small Cell Lung Carcinoma	GDSC	PTATPSST	DEG_SCF_FBW7_1	0.25
p.A3147G	SIDM00736	Non-Cancerous	GDSC	PTATPSST	DEG_SCF_FBW7_1	0.25
p.A3147G	SIDM01592	Breast Carcinoma	GDSC	PTATPSST	DEG_SCF_FBW7_1	0.25
p.A3147G	L-1236	haematopoietic_and_lymphoid_tissue	COSMIC	PTATPSST	DEG_SCF_FBW7_1	0.25
p.A3147G	GRANTA-519	haematopoietic_and_lymphoid_tissue	COSMIC	PTATPSST	DEG_SCF_FBW7_1	0.25
p.A3146P	TCGA-AA-3848	COAD	TCGA	PTATPSST	DEG_SCF_FBW7_1	0.2222
p.A3147T	TCGA-AP-A051	UCEC	TCGA	PTATPSST	DEG_SCF_FBW7_1	0.25
p.A3149P	DO9740	COAD	ICGC	PTATPSST	DEG_SCF_FBW7_1	0.3056
p.A3150V	DO222492	COCA	ICGC	PTATPSST	DEG_SCF_FBW7_1	0.6936
p.A3150T	DO222755	COCA	ICGC	PTATPSST	DEG_SCF_FBW7_1	0.7139
p.A3150T	DO42673	UCEC	ICGC	PTATPSST	DEG_SCF_FBW7_1	0.7139
p.T3154M	DO229010	COCA	ICGC	PTATPSST	DEG_SCF_FBW7_1	0.7423
p.T3154M	DO229013	COCA	ICGC	PTATPSST	DEG_SCF_FBW7_1	0.7423
p.T3154M	DO229016	COCA	ICGC	PTATPSST	DEG_SCF_FBW7_1	0.7423
p.T3154M	DO229003	COCA	ICGC	PTATPSST	DEG_SCF_FBW7_1	0.7423
p.T3154M	DO229005	COCA	ICGC	PTATPSST	DEG_SCF_FBW7_1	0.7423
p.T3154M	DO233731	GACA	ICGC	PTATPSST	DEG_SCF_FBW7_1	0.7423
p.T3154M	DO229346	LAML	ICGC	PTATPSST	DEG_SCF_FBW7_1	0.7423
p.T3154M	DO52365	LUSC	ICGC	PTATPSST	DEG_SCF_FBW7_1	0.7423
p.A3150G	DO24140	LUAD	ICGC	PTATPSST	DEG_SCF_FBW7_1	0.754
p.G3162E	DO229453	SKCA	ICGC	PTATPSST	DEG_SCF_FBW7_1	0.1944
p.P3154L	SIDM00266	Ewing's Sarcoma	GDSC	PTATPSST	DEG_SCF_FBW7_1	0.7582
p.P3154L	SIDM00362	Burkitt's Lymphoma	GDSC	PTATPSST	DEG_SCF_FBW7_1	0.7582
p.P3154L	SIDM00690	Head and Neck Carcinoma	GDSC	PTATPSST	DEG_SCF_FBW7_1	0.7582
p.P3154L	SIDM00230	Small Cell Lung Carcinoma	GDSC	PTATPSST	DEG_SCF_FBW7_1	0.7582
p.T3151K	SIDM01387	Small Cell Lung Carcinoma	GDSC	PTATPSST	DEG_SCF_FBW7_1	0.6195
p.T3165I	ACH-002669	Colon/Colorectal Cancer	CCLE	PTATPSST	DEG_SCF_FBW7_1	0.1111
p.T3153N	SH-4	skin	COSMIC	PTATPSST	DEG_SCF_FBW7_1	0.7055

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PTATPSST

Degron related mutations and impact score

Drug responses associated with MUC5B mutations

All proteins holding degron of PTATPSST

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9HC84	Mucin-5B	DEG_SCF_FBW7_1	3150:3157	PTATPSST	FBXW7	0.9919	More...
Q9HC84	Mucin-5B	DEG_SCF_FBW7_1	4407:4414	PTATPSST	FBXW7	0.9783	More...