DegronMD

Uniprot ID: Q9HC84

Source protein: Mucin-5B

Source gene: MUC5B

Class: DEG_SCF_FBW7_1

Location: 4407:4414

E3 ligase: FBXW7

DEGRON score: 0.9783

ASA_SCORE: 84.5375

COIL: 0.9204

CONS_SCORE: 0.323

DSS_SCORE: 0.6416

HELIX: 0.0173

FCONS_SCORE: 1.1126

RIG_SCORE: 0.6803

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E4423K	TCGA-67-3771	LUAD	TCGA	PTATPSST	DEG_SCF_FBW7_1	0.0833
p.A4404T	TCGA-AD-6964	COAD	TCGA	PTATPSST	DEG_SCF_FBW7_1	0.25
p.P4407T	TCGA-AP-A1DM	UCEC	TCGA	PTATPSST	DEG_SCF_FBW7_1	0.7031
p.T4408M	TCGA-EE-A2MT	SKCM	TCGA	PTATPSST	DEG_SCF_FBW7_1	0.6312
p.T4408M	SNU-1040	large_intestine	COSMIC	PTATPSST	DEG_SCF_FBW7_1	0.6312
p.A4407T	DO8360	COAD	ICGC	PTATPSST	DEG_SCF_FBW7_1	0.7139
p.T4411M	DO222839	COCA	ICGC	PTATPSST	DEG_SCF_FBW7_1	0.7423
p.T4411M	DO229347	LAML	ICGC	PTATPSST	DEG_SCF_FBW7_1	0.7423
p.T4411M	DO228947	LICA	ICGC	PTATPSST	DEG_SCF_FBW7_1	0.7423
p.T4411M	DO229028	LICA	ICGC	PTATPSST	DEG_SCF_FBW7_1	0.7423
p.T4411M	DO224551	LUSC	ICGC	PTATPSST	DEG_SCF_FBW7_1	0.7423
p.T4411M	DO38051	SKCM	ICGC	PTATPSST	DEG_SCF_FBW7_1	0.7423
p.A4407G	DO229010	COCA	ICGC	PTATPSST	DEG_SCF_FBW7_1	0.754
p.A4407G	DO229013	COCA	ICGC	PTATPSST	DEG_SCF_FBW7_1	0.754
p.A4407G	DO229016	COCA	ICGC	PTATPSST	DEG_SCF_FBW7_1	0.754
p.A4407G	DO229003	COCA	ICGC	PTATPSST	DEG_SCF_FBW7_1	0.754
p.A4407G	DO229005	COCA	ICGC	PTATPSST	DEG_SCF_FBW7_1	0.754
p.A4407G	DO229346	LAML	ICGC	PTATPSST	DEG_SCF_FBW7_1	0.754
p.A4407G	DO229006	LICA	ICGC	PTATPSST	DEG_SCF_FBW7_1	0.754
p.A4407G	DO46969	RECA	ICGC	PTATPSST	DEG_SCF_FBW7_1	0.754
p.T4405A	DO232761	PBCA	ICGC	PTATPSST	DEG_SCF_FBW7_1	0.2778
p.P4410T	DO43106	UCEC	ICGC	PTATPSST	DEG_SCF_FBW7_1	0.7031
p.T4418I	SIDM00864	Cervical Carcinoma	GDSC	PTATPSST	DEG_SCF_FBW7_1	0.2222
p.T4418I	DoTc2-4510	cervix	COSMIC	PTATPSST	DEG_SCF_FBW7_1	0.2222
p.P4415T	SIDM01140	Ovarian Carcinoma	GDSC	PTATPSST	DEG_SCF_FBW7_1	0.3056
p.P4411L	NCI-H2347	lung	COSMIC	PTATPSST	DEG_SCF_FBW7_1	0.7582
p.P4411L	DBTRG-05MG	central_nervous_system	COSMIC	PTATPSST	DEG_SCF_FBW7_1	0.7582
p.P4411L	U-CH2	bone	COSMIC	PTATPSST	DEG_SCF_FBW7_1	0.7582

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9HC84	Mucin-5B	DEG_SCF_FBW7_1	3150:3157	PTATPSST	FBXW7	0.9919	More...
Q9HC84	Mucin-5B	DEG_SCF_FBW7_1	4407:4414	PTATPSST	FBXW7	0.9783	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PTATPSST

Degron related mutations and impact score

Drug responses associated with MUC5B mutations

All proteins holding degron of PTATPSST