DegronMD

Uniprot ID: O60928

Source protein: Inward rectifier potassium channel 13

Source gene: KCNJ13

Class: DEG_SCF_FBW7_1

Location: 326:331

E3 ligase: FBXW7

DEGRON score: 0.9888

ASA_SCORE: 69.7667

COIL: 0.9317

CONS_SCORE: 0.3736

DSS_SCORE: 0.5286

HELIX: 0.0172

FCONS_SCORE: 0.9921

RIG_SCORE: 0.7455

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P328H	TCGA-DF-A2KU	UCEC	TCGA	PTPLVS	DEG_SCF_FBW7_1	0.7694
p.P328H	DO223286	UCEC	ICGC	PTPLVS	DEG_SCF_FBW7_1	0.7694
p.L329P	TCGA-UB-A7MD	LIHC	TCGA	PTPLVS	DEG_SCF_FBW7_1	0.6471
p.L329P	DO52320	LIHC	ICGC	PTPLVS	DEG_SCF_FBW7_1	0.6471
p.L339V	SIDM01117	Small Cell Lung Carcinoma	GDSC	PTPLVS	DEG_SCF_FBW7_1	0.1111
p.L339V	ACH-002176	Lung Cancer	CCLE	PTPLVS	DEG_SCF_FBW7_1	0.1111
p.L339V	NCI-H748	lung	COSMIC	PTPLVS	DEG_SCF_FBW7_1	0.1111
p.P328R	SIDM00711	Squamous Cell Lung Carcinoma	GDSC	PTPLVS	DEG_SCF_FBW7_1	0.7512
p.P328R	ACH-000727	Lung Cancer	CCLE	PTPLVS	DEG_SCF_FBW7_1	0.7512
p.P328R	NCI-H2066	lung	COSMIC	PTPLVS	DEG_SCF_FBW7_1	0.7512

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60928	Inward rectifier potassium channel 13	DEG_SCF_FBW7_1	326:331	PTPLVS	FBXW7	0.9888	More...
Q2KHR3	Glutamine and serine-rich protein 1	DEG_SCF_FBW7_1	1200:1205	PTPLVS	FBXW7	0.998	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons