DegronMD

Uniprot ID: Q2KHR3

Source protein: Glutamine and serine-rich protein 1

Source gene: QSER1

Class: DEG_SCF_FBW7_1

Location: 1200:1205

E3 ligase: FBXW7

DEGRON score: 0.998

ASA_SCORE: 88.0333

COIL: 0.9232

CONS_SCORE: 0.4854

DSS_SCORE: 0.7528

HELIX: 0.0367

FCONS_SCORE: 1.0926

RIG_SCORE: 0.6371

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K1194N	TCGA-06-1802	GBM	TCGA	PTPLVS	DEG_SCF_FBW7_1	0.2778
p.K1194N	DO12100	GBM	ICGC	PTPLVS	DEG_SCF_FBW7_1	0.2778
p.N1210S	TCGA-19-5956	GBM	TCGA	PTPLVS	DEG_SCF_FBW7_1	0.1944
p.N1210S	DO13863	GBM	ICGC	PTPLVS	DEG_SCF_FBW7_1	0.1944
p.P1191L	TCGA-95-A4VN	LUAD	TCGA	PTPLVS	DEG_SCF_FBW7_1	0.0833
p.P1191L	DO51199	LUAD	ICGC	PTPLVS	DEG_SCF_FBW7_1	0.0833
p.V1204M	TCGA-C8-A12K	BRCA	TCGA	PTPLVS	DEG_SCF_FBW7_1	0.6097
p.V1204M	DO1258	BRCA	ICGC	PTPLVS	DEG_SCF_FBW7_1	0.6097
p.P1212L	TCGA-CV-7568	HNSC	TCGA	PTPLVS	DEG_SCF_FBW7_1	0.1389
p.P1212L	DO14160	HNSC	ICGC	PTPLVS	DEG_SCF_FBW7_1	0.1389
p.G1209S	DO234230	ESAD	ICGC	PTPLVS	DEG_SCF_FBW7_1	0.2222
p.T1201I	DO35242	PACA	ICGC	PTPLVS	DEG_SCF_FBW7_1	0.7078
p.T1214I	KMS-11	haematopoietic_and_lymphoid_tissue	COSMIC	PTPLVS	DEG_SCF_FBW7_1	0.0833
p.E1192K	NCI-H1781	lung	COSMIC	PTPLVS	DEG_SCF_FBW7_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60928	Inward rectifier potassium channel 13	DEG_SCF_FBW7_1	326:331	PTPLVS	FBXW7	0.9888	More...
Q2KHR3	Glutamine and serine-rich protein 1	DEG_SCF_FBW7_1	1200:1205	PTPLVS	FBXW7	0.998	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons