DegronMD: protein-targeted degradation, mutation and drug response to degrons
Home
(current)
Browse
Proteins/Degrons
Mutations
Drug response
Network-rewiring
Drug resistance
Search
Tutorial
Download
Contact
Links
BSML
CPH
CGC
Degron:
PTPRKS
Uniprot ID:
Q9Y4E1
Source protein:
WASH complex subunit 2C
Source gene:
WASHC2C
Class:
DEG_SCF_FBW7_1
Location:
436:441
E3 ligase:
FBXW7
DEGRON score:
0.7927
ASA_SCORE:
106.1833
COIL:
0.9595
CONS_SCORE:
0.3624
DSS_SCORE:
0.893
HELIX:
0.0142
FCONS_SCORE:
0.9321
RIG_SCORE:
0.5681
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with WASHC2C mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PTPRKS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q641Q2
WASH complex subunit 2A
DEG_SCF_FBW7_1
436:441
PTPRKS
FBXW7
0.8789
More...
Q9Y4E1
WASH complex subunit 2C
DEG_SCF_FBW7_1
436:441
PTPRKS
FBXW7
0.7927
More...