DegronMD - Q9Y4E1(WASHC2C)

WASHC2C

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A1100V	SIDM01095	Rhabdomyosarcoma	GDSC	DSGDIFS	DEG_SCF_TRCP1_1	1110:1116	Mutation rewiring degron network	0.0556
p.E670D	SIDM00352	Ovarian Carcinoma	GDSC	KTSLFEE	LIG_APCC_ABBAyCdc20_2	661:667	Mutation rewiring degron network	0.25
p.E670D	RMG-I	ovary	COSMIC	KTSLFEE	LIG_APCC_ABBAyCdc20_2	661:667	Mutation rewiring degron network	0.25
p.G1105R	SIDM00135	Breast Carcinoma	GDSC	DSGDIFS	DEG_SCF_TRCP1_1	1110:1116	Mutation rewiring degron network	0.1944
p.S1123F	SIDM01175	Other Sarcomas	GDSC	DSGDIFS	DEG_SCF_TRCP1_1	1110:1116	Mutation blocking phosphorylation signal	0.5833
p.G1106S	SIDM00729	Non-Small Cell Lung Carcinoma	GDSC	DSGDIFS	DEG_SCF_TRCP1_1	1110:1116	Mutation rewiring degron network	0.2222
p.A677T	SIDM00217	Colorectal Carcinoma	GDSC	KTSLFEE	LIG_APCC_ABBAyCdc20_2	661:667	Mutation rewiring degron network	0.0556
p.A677T	SNU-1040	large intestine	COSMIC	KTSLFEE	LIG_APCC_ABBAyCdc20_2	661:667	Mutation rewiring degron network	0.0556
p.A653T	SNU-1040	large intestine	COSMIC	KTSLFEE	LIG_APCC_ABBAyCdc20_2	661:667	Mutation blocking phosphorylation signal	0.5556
p.D655N	SK-MEL-3	skin	COSMIC	KTSLFEE	LIG_APCC_ABBAyCdc20_2	661:667	Mutation rewiring degron network	0.1667
p.S815Y	SNU-407	large intestine	COSMIC	LSLFDE	LIG_APCC_ABBA_1	801:806	Mutation rewiring degron network	0.0833

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*NOTE: the Kaplan plots were collected from OncoLnc