DegronMD

Uniprot ID: Q9Y4E1

Source protein: WASH complex subunit 2C

Source gene: WASHC2C

Class: DEG_SCF_TRCP1_1

Location: 1110:1116

E3 ligase: BTRC

DEGRON score: 0.999

ASA_SCORE: 63.9571

COIL: 0.8484

CONS_SCORE: 0.4435

DSS_SCORE: 0.5416

HELIX: 0.1033

FCONS_SCORE: 1.1971

RIG_SCORE: 0.715

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A1100V	SIDM01095	Rhabdomyosarcoma	GDSC	DSGDIFS	DEG_SCF_TRCP1_1	0.0556
p.G1105R	SIDM00135	Breast Carcinoma	GDSC	DSGDIFS	DEG_SCF_TRCP1_1	0.1944
p.S1123F	SIDM01175	Other Sarcomas	GDSC	DSGDIFS	DEG_SCF_TRCP1_1	0.5833
p.G1106S	SIDM00729	Non-Small Cell Lung Carcinoma	GDSC	DSGDIFS	DEG_SCF_TRCP1_1	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons