DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
DSGDIFS
Uniprot ID:
Q641Q2
Source protein:
WASH complex subunit 2A
Source gene:
WASHC2A
Class:
DEG_SCF_TRCP1_1
Location:
1131:1137
E3 ligase:
BTRC
DEGRON score:
0.9993
ASA_SCORE:
61.6429
COIL:
0.8433
CONS_SCORE:
0.5253
DSS_SCORE:
0.54
HELIX:
0.1117
FCONS_SCORE:
1.4937
RIG_SCORE:
0.7102
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.T1138M
SIDM00429
B-Lymphoblastic Leukemia
GDSC
DSGDIFS
DEG_SCF_TRCP1_1
0.3056
p.D1131N
SIDM00628
Breast Carcinoma
GDSC
DSGDIFS
DEG_SCF_TRCP1_1
0.6932
Drug responses associated with WASHC2A mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of DSGDIFS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q641Q2
WASH complex subunit 2A
DEG_SCF_TRCP1_1
1131:1137
DSGDIFS
BTRC
0.9993
More...
Q9Y4E1
WASH complex subunit 2C
DEG_SCF_TRCP1_1
1110:1116
DSGDIFS
BTRC
0.999
More...