DegronMD

Uniprot ID: Q9Y4E1

Source protein: WASH complex subunit 2C

Source gene: WASHC2C

Class: LIG_APCC_ABBAyCdc20_2

Location: 661:667

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.997

ASA_SCORE: 101.1

COIL: 0.5806

CONS_SCORE: 0.4779

DSS_SCORE: 0.4362

HELIX: 0.3871

FCONS_SCORE: 1.1714

RIG_SCORE: 0.7536

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E670D	SIDM00352	Ovarian Carcinoma	GDSC	KTSLFEE	LIG_APCC_ABBAyCdc20_2	0.25
p.E670D	RMG-I	ovary	COSMIC	KTSLFEE	LIG_APCC_ABBAyCdc20_2	0.25
p.A677T	SIDM00217	Colorectal Carcinoma	GDSC	KTSLFEE	LIG_APCC_ABBAyCdc20_2	0.0556
p.A677T	SNU-1040	large_intestine	COSMIC	KTSLFEE	LIG_APCC_ABBAyCdc20_2	0.0556
p.A653T	SNU-1040	large_intestine	COSMIC	KTSLFEE	LIG_APCC_ABBAyCdc20_2	0.5556
p.D655N	SK-MEL-3	skin	COSMIC	KTSLFEE	LIG_APCC_ABBAyCdc20_2	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons