DegronMD

Uniprot ID: Q641Q2

Source protein: WASH complex subunit 2A

Source gene: WASHC2A

Class: LIG_APCC_ABBAyCdc20_2

Location: 661:667

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9998

ASA_SCORE: 101.0286

COIL: 0.7

CONS_SCORE: 0.5345

DSS_SCORE: 0.4741

HELIX: 0.2679

FCONS_SCORE: 1.3255

RIG_SCORE: 0.7465

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A656V	SIDM01029	Esophageal Squamous Cell Carcinoma	GDSC	KTSLFEE	LIG_APCC_ABBAyCdc20_2	0.1944
p.D672A	SIDM01588	Endometrial Carcinoma	GDSC	KTSLFEE	LIG_APCC_ABBAyCdc20_2	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons