DegronMD

Degron: PTTPSLS

Uniprot ID: Q9UKN1

Source protein: Mucin-12

Source gene: MUC12

Class: DEG_SCF_FBW7_1

Location: 1431:1437

E3 ligase: FBXW7

DEGRON score: 0.7364

ASA_SCORE: 86.2857

COIL: 0.8669

CONS_SCORE: 0

DSS_SCORE: 0.6853

HELIX: 0.0224

FCONS_SCORE: 0

RIG_SCORE: 0.6068

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1431H	HSC-2	upper_aerodigestive_tract	COSMIC	PTTPSLS	DEG_SCF_FBW7_1	0.7694
p.T1426A	DO229030	LICA	ICGC	PTTPSLS	DEG_SCF_FBW7_1	0.1944

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Drug responses associated with MUC12 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
No data available in table

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All proteins holding degron of PTTPSLS

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UKN1	Mucin-12	DEG_SCF_FBW7_1	1431:1437	PTTPSLS	FBXW7	0.7364	More...
Q9UKN1	Mucin-12	DEG_SCF_FBW7_1	2514:2520	PTTPSLS	FBXW7	0.7881	More...
Q9UKN1	Mucin-12	DEG_SCF_FBW7_1	2988:2994	PTTPSLS	FBXW7	0.5577	More...
Q9UKN1	Mucin-12	DEG_SCF_FBW7_1	4071:4077	PTTPSLS	FBXW7	0.5577	More...

Showing 1 to 4 of 4 entries