DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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CGC
Degron:
PTTPSLS
Uniprot ID:
Q9UKN1
Source protein:
Mucin-12
Source gene:
MUC12
Class:
DEG_SCF_FBW7_1
Location:
1431:1437
E3 ligase:
FBXW7
DEGRON score:
0.7364
ASA_SCORE:
86.2857
COIL:
0.8669
CONS_SCORE:
0
DSS_SCORE:
0.6853
HELIX:
0.0224
FCONS_SCORE:
0
RIG_SCORE:
0.6068
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.T1426A
DO229030
LICA
ICGC
PTTPSLS
DEG_SCF_FBW7_1
0.1944
p.P1431H
HSC-2
upper_aerodigestive_tract
COSMIC
PTTPSLS
DEG_SCF_FBW7_1
0.7694
Drug responses associated with MUC12 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PTTPSLS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9UKN1
Mucin-12
DEG_SCF_FBW7_1
1431:1437
PTTPSLS
FBXW7
0.7364
More...
Q9UKN1
Mucin-12
DEG_SCF_FBW7_1
2514:2520
PTTPSLS
FBXW7
0.7881
More...
Q9UKN1
Mucin-12
DEG_SCF_FBW7_1
2988:2994
PTTPSLS
FBXW7
0.5577
More...
Q9UKN1
Mucin-12
DEG_SCF_FBW7_1
4071:4077
PTTPSLS
FBXW7
0.5577
More...