DegronMD

Uniprot ID: Q9UKN1

Source protein: Mucin-12

Source gene: MUC12

Class: DEG_SCF_FBW7_1

Location: 4071:4077

E3 ligase: FBXW7

DEGRON score: 0.5577

ASA_SCORE: 87.4429

COIL: 0.8884

CONS_SCORE: 0

DSS_SCORE: 0.6853

HELIX: 0.0191

FCONS_SCORE: 0

RIG_SCORE: 0.6068

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G4069C	DO230940	LUSC	ICGC	PTTPSLS	DEG_SCF_FBW7_1	0.2778
p.G4069C	DO224584	LUSC	ICGC	PTTPSLS	DEG_SCF_FBW7_1	0.2778
p.G4072A	SIDM01066	Melanoma	GDSC	PTTPSLS	DEG_SCF_FBW7_1	0.754
p.G4072A	IGR-37	skin	COSMIC	PTTPSLS	DEG_SCF_FBW7_1	0.754

DegronMD: protein-targeted degradation, mutation and drug response to degrons