DegronMD

Uniprot ID: A1L4H1

Source protein: Soluble scavenger receptor cysteine-rich domain-containing protein SSC5D

Source gene: SSC5D

Class: DEG_SCF_FBW7_1

Location: 1151:1158

E3 ligase: FBXW7

DEGRON score: 0.9897

ASA_SCORE: 94.9375

COIL: 0.9563

CONS_SCORE: -1000

DSS_SCORE: 0.8154

HELIX: 0.0189

FCONS_SCORE: 2.0006

RIG_SCORE: 0.5502

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1148N	TCGA-A5-A0G1	UCEC	TCGA	PTTTPDPT	DEG_SCF_FBW7_1	0.25
p.S1148N	DO42472	UCEC	ICGC	PTTTPDPT	DEG_SCF_FBW7_1	0.25
p.A1160D	TCGA-AZ-6601	COAD	TCGA	PTTTPDPT	DEG_SCF_FBW7_1	0.2778
p.A1160D	DO8119	COAD	ICGC	PTTTPDPT	DEG_SCF_FBW7_1	0.2778
p.T1152P	DO228912	LICA	ICGC	PTTTPDPT	DEG_SCF_FBW7_1	0.5919
p.H1150P	DO48573	PAEN	ICGC	PTTTPDPT	DEG_SCF_FBW7_1	0.3056
p.I1164T	ARH-77	haematopoietic_and_lymphoid_tissue	COSMIC	PTTTPDPT	DEG_SCF_FBW7_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A1L4H1	Soluble scavenger receptor cysteine-rich domain-containing protein SSC5D	DEG_SCF_FBW7_1	1151:1158	PTTTPDPT	FBXW7	0.9897	More...
A1L4H1	Soluble scavenger receptor cysteine-rich domain-containing protein SSC5D	DEG_SCF_FBW7_1	1313:1320	PTTTPDPT	FBXW7	0.9081	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons