DegronMD

Uniprot ID: A1L4H1

Source protein: Soluble scavenger receptor cysteine-rich domain-containing protein SSC5D

Source gene: SSC5D

Class: DEG_SCF_FBW7_1

Location: 1313:1320

E3 ligase: FBXW7

DEGRON score: 0.9081

ASA_SCORE: 99.4875

COIL: 0.9701

CONS_SCORE: 0.3952

DSS_SCORE: 0.7633

HELIX: 0.0108

FCONS_SCORE: 0.9346

RIG_SCORE: 0.5806

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D1318H	DO228957	LICA	ICGC	PTTTPDPT	DEG_SCF_FBW7_1	0.6577
p.D1318H	DO229028	LICA	ICGC	PTTTPDPT	DEG_SCF_FBW7_1	0.6577
p.D1318H	DO229008	LICA	ICGC	PTTTPDPT	DEG_SCF_FBW7_1	0.6577
p.Y1312D	DO51017	LAML	ICGC	PTTTPDPT	DEG_SCF_FBW7_1	0.3056
p.Y1312H	DO229028	LICA	ICGC	PTTTPDPT	DEG_SCF_FBW7_1	0.3056
p.Y1312H	DO229031	LICA	ICGC	PTTTPDPT	DEG_SCF_FBW7_1	0.3056
p.T1321M	SIDM00431	T-Lymphoblastic Leukemia	GDSC	PTTTPDPT	DEG_SCF_FBW7_1	0.3056
p.T1321M	ACH-000918	Leukemia	CCLE	PTTTPDPT	DEG_SCF_FBW7_1	0.3056
p.T1321M	MOLT-16	haematopoietic_and_lymphoid_tissue	COSMIC	PTTTPDPT	DEG_SCF_FBW7_1	0.3056

Showing 1 to 9 of 9 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A1L4H1	Soluble scavenger receptor cysteine-rich domain-containing protein SSC5D	DEG_SCF_FBW7_1	1151:1158	PTTTPDPT	FBXW7	0.9897	More...
A1L4H1	Soluble scavenger receptor cysteine-rich domain-containing protein SSC5D	DEG_SCF_FBW7_1	1313:1320	PTTTPDPT	FBXW7	0.9081	More...

Showing 1 to 2 of 2 entries

DegronMD: protein-targeted degradation, mutation and drug response to degrons