DegronMD

Uniprot ID: A1L4H1

Source protein: Soluble scavenger receptor cysteine-rich domain-containing protein SSC5D

Source gene: SSC5D

Class: DEG_SCF_FBW7_1

Location: 1241:1248

E3 ligase: FBXW7

DEGRON score: 0.7903

ASA_SCORE: 90.85

COIL: 0.9496

CONS_SCORE: 0.3696

DSS_SCORE: 0.7824

HELIX: 0.0168

FCONS_SCORE: 1.0479

RIG_SCORE: 0.5708

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1241S	TCGA-AP-A1DK	UCEC	TCGA	PTTTPHPT	DEG_SCF_FBW7_1	0.6752
p.P1241S	DO42033	UCEC	ICGC	PTTTPHPT	DEG_SCF_FBW7_1	0.6752
p.H1246Q	DO228947	LICA	ICGC	PTTTPHPT	DEG_SCF_FBW7_1	0.647
p.H1246Q	DO229259	THCA	ICGC	PTTTPHPT	DEG_SCF_FBW7_1	0.647
p.P1247L	DO220891	MELA	ICGC	PTTTPHPT	DEG_SCF_FBW7_1	0.6471
p.T1254P	DO229211	THCA	ICGC	PTTTPHPT	DEG_SCF_FBW7_1	0.1667
p.T1243M	SIDM00068	Colorectal Carcinoma	GDSC	PTTTPHPT	DEG_SCF_FBW7_1	0.6312

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A1L4H1	Soluble scavenger receptor cysteine-rich domain-containing protein SSC5D	DEG_SCF_FBW7_1	1241:1248	PTTTPHPT	FBXW7	0.7903	More...
A1L4H1	Soluble scavenger receptor cysteine-rich domain-containing protein SSC5D	DEG_SCF_FBW7_1	1289:1296	PTTTPHPT	FBXW7	0.6998	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons