DegronMD

Uniprot ID: A1L4H1

Source protein: Soluble scavenger receptor cysteine-rich domain-containing protein SSC5D

Source gene: SSC5D

Class: DEG_SCF_FBW7_1

Location: 1289:1296

E3 ligase: FBXW7

DEGRON score: 0.6998

ASA_SCORE: 102.1875

COIL: 0.973

CONS_SCORE: 0.4534

DSS_SCORE: 0.803

HELIX: 0.0105

FCONS_SCORE: 1.0306

RIG_SCORE: 0.5107

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T1279M	TCGA-CM-5348	COAD	TCGA	PTTTPHPT	DEG_SCF_FBW7_1	0.0556
p.T1279M	DO9514	COAD	ICGC	PTTTPHPT	DEG_SCF_FBW7_1	0.0556
p.T1279M	DO222703	COCA	ICGC	PTTTPHPT	DEG_SCF_FBW7_1	0.0556
p.P1293S	TCGA-G3-A25W	LIHC	TCGA	PTTTPHPT	DEG_SCF_FBW7_1	0.6752
p.P1293S	DO22970	LIHC	ICGC	PTTTPHPT	DEG_SCF_FBW7_1	0.6752
p.H1294Y	DO229005	COCA	ICGC	PTTTPHPT	DEG_SCF_FBW7_1	0.6118
p.H1294Y	DO228941	LICA	ICGC	PTTTPHPT	DEG_SCF_FBW7_1	0.6118
p.H1294Y	DO228947	LICA	ICGC	PTTTPHPT	DEG_SCF_FBW7_1	0.6118
p.H1294Y	DO229047	LICA	ICGC	PTTTPHPT	DEG_SCF_FBW7_1	0.6118
p.H1294Y	DO229006	LICA	ICGC	PTTTPHPT	DEG_SCF_FBW7_1	0.6118
p.T1290P	DO229216	THCA	ICGC	PTTTPHPT	DEG_SCF_FBW7_1	0.5919

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A1L4H1	Soluble scavenger receptor cysteine-rich domain-containing protein SSC5D	DEG_SCF_FBW7_1	1241:1248	PTTTPHPT	FBXW7	0.7903	More...
A1L4H1	Soluble scavenger receptor cysteine-rich domain-containing protein SSC5D	DEG_SCF_FBW7_1	1289:1296	PTTTPHPT	FBXW7	0.6998	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons