DegronMD

Uniprot ID: P20265

Source protein: POU domain, class 3, transcription factor 2

Source gene: POU3F2

Class: DEG_SPOP_SBC_1

Location: 92:96

E3 ligase: SPOP

DEGRON score: 0.9961

ASA_SCORE: 76.96

COIL: 0.9268

CONS_SCORE: 0.4086

DSS_SCORE: 0.8164

HELIX: 0.0138

FCONS_SCORE: 1.0728

RIG_SCORE: 0.6529

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G99S	TCGA-GL-A9DD	KIRP	TCGA	PWSTS	DEG_SPOP_SBC_1	0.25
p.G99S	DO51558	KIRP	ICGC	PWSTS	DEG_SPOP_SBC_1	0.25
p.G86V	DO224630	LUSC	ICGC	PWSTS	DEG_SPOP_SBC_1	0.1667
p.P97S	DO229462	SKCA	ICGC	PWSTS	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P20265	POU domain, class 3, transcription factor 2	DEG_SPOP_SBC_1	92:96	PWSTS	SPOP	0.9961	More...
Q5W0B1	ORC ubiquitin ligase 1	DEG_SPOP_SBC_1	689:693	PWSTS	SPOP	0.8729	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons