DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
PWSTS
Uniprot ID:
Q5W0B1
Source protein:
ORC ubiquitin ligase 1
Source gene:
OBI1
Class:
DEG_SPOP_SBC_1
Location:
689:693
E3 ligase:
SPOP
DEGRON score:
0.8729
ASA_SCORE:
68.28
COIL:
0.7066
CONS_SCORE:
0.2969
DSS_SCORE:
0.51
HELIX:
0.1872
FCONS_SCORE:
1.0226
RIG_SCORE:
0.6812
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with OBI1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PWSTS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P20265
POU domain, class 3, transcription factor 2
DEG_SPOP_SBC_1
92:96
PWSTS
SPOP
0.9961
More...
Q5W0B1
ORC ubiquitin ligase 1
DEG_SPOP_SBC_1
689:693
PWSTS
SPOP
0.8729
More...