DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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CGC
Degron:
RELVFKE
Uniprot ID:
O14602
Source protein:
Eukaryotic translation initiation factor 1A, Y-chromosomal
Source gene:
EIF1AY
Class:
LIG_APCC_ABBAyCdc20_2
Location:
24:30
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.6681
ASA_SCORE:
92.1
COIL:
0.4317
CONS_SCORE:
0.8383
DSS_SCORE:
0.4609
HELIX:
0.0716
FCONS_SCORE:
1.0329
RIG_SCORE:
0.8024
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with EIF1AY mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of RELVFKE
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P47813
Eukaryotic translation initiation factor 1A, X-chromosomal
LIG_APCC_ABBAyCdc20_2
24:30
RELVFKE
APC,CDC20,FZR1
0.8191
More...
O14602
Eukaryotic translation initiation factor 1A, Y-chromosomal
LIG_APCC_ABBAyCdc20_2
24:30
RELVFKE
APC,CDC20,FZR1
0.6681
More...