DegronMD

Uniprot ID: P47813

Source protein: Eukaryotic translation initiation factor 1A, X-chromosomal

Source gene: EIF1AX

Class: LIG_APCC_ABBAyCdc20_2

Location: 24:30

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8191

ASA_SCORE: 92.1429

COIL: 0.4686

CONS_SCORE: 0.8412

DSS_SCORE: 0.471

HELIX: 0.0656

FCONS_SCORE: 1.0286

RIG_SCORE: 0.8015

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R14W	TCGA-50-5049	LUAD	TCGA	RELVFKE	LIG_APCC_ABBAyCdc20_2	0.0556
p.R14W	DO23705	LUAD	ICGC	RELVFKE	LIG_APCC_ABBAyCdc20_2	0.0556
p.A36T	TCGA-D7-A4YV	STAD	TCGA	RELVFKE	LIG_APCC_ABBAyCdc20_2	0.1667
p.A36T	DO47777	STAD	ICGC	RELVFKE	LIG_APCC_ABBAyCdc20_2	0.1667
p.G15V	TCGA-DB-A4XB	LGG	TCGA	RELVFKE	LIG_APCC_ABBAyCdc20_2	0.0833
p.G15V	DO230344	COCA	ICGC	RELVFKE	LIG_APCC_ABBAyCdc20_2	0.0833
p.G15V	DO44546	LGG	ICGC	RELVFKE	LIG_APCC_ABBAyCdc20_2	0.0833
p.G15V	DO222753	MELA	ICGC	RELVFKE	LIG_APCC_ABBAyCdc20_2	0.0833
p.G15D	TCGA-DU-A5TP	LGG	TCGA	RELVFKE	LIG_APCC_ABBAyCdc20_2	0.0833
p.G15D	TCGA-V4-A9F7	UVM	TCGA	RELVFKE	LIG_APCC_ABBAyCdc20_2	0.0833
p.G15D	TCGA-WC-A87U	UVM	TCGA	RELVFKE	LIG_APCC_ABBAyCdc20_2	0.0833
p.G15D	DO44562	LGG	ICGC	RELVFKE	LIG_APCC_ABBAyCdc20_2	0.0833
p.R14G	SIDM00516	Melanoma	GDSC	RELVFKE	LIG_APCC_ABBAyCdc20_2	0.0556
p.R14G	ACH-002166	Skin Cancer	CCLE	RELVFKE	LIG_APCC_ABBAyCdc20_2	0.0556
p.R14G	MZ7-mel	skin	COSMIC	RELVFKE	LIG_APCC_ABBAyCdc20_2	0.0556
p.R34G	OPM-2	haematopoietic_and_lymphoid_tissue	COSMIC	RELVFKE	LIG_APCC_ABBAyCdc20_2	0.2222
p.H32D	NCI-H196	lung	COSMIC	RELVFKE	LIG_APCC_ABBAyCdc20_2	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P47813	Eukaryotic translation initiation factor 1A, X-chromosomal	LIG_APCC_ABBAyCdc20_2	24:30	RELVFKE	APC,CDC20,FZR1	0.8191	More...
O14602	Eukaryotic translation initiation factor 1A, Y-chromosomal	LIG_APCC_ABBAyCdc20_2	24:30	RELVFKE	APC,CDC20,FZR1	0.6681	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons