DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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Degron:
RRQELARLR
Uniprot ID:
Q15695
Source protein:
Putative U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 1
Source gene:
ZRSR2P1
Class:
DEG_APCC_DBOX_1
Location:
36:44
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.814
ASA_SCORE:
109.9333
COIL:
0.033
CONS_SCORE:
0.5007
DSS_SCORE:
0.5667
HELIX:
0.9702
FCONS_SCORE:
1.1215
RIG_SCORE:
0.7161
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with ZRSR2P1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of RRQELARLR
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q15696
U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2
DEG_APCC_DBOX_1
30:38
RRQELARLR
APC,CDC20,FZR1
0.8035
More...
Q15695
Putative U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 1
DEG_APCC_DBOX_1
36:44
RRQELARLR
APC,CDC20,FZR1
0.814
More...