DegronMD

Uniprot ID: Q15696

Source protein: U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2

Source gene: ZRSR2

Class: DEG_APCC_DBOX_1

Location: 30:38

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8035

ASA_SCORE: 109.9667

COIL: 0.0439

CONS_SCORE: 0.4363

DSS_SCORE: 0.5679

HELIX: 0.9598

FCONS_SCORE: 1.098

RIG_SCORE: 0.7178

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q32H	TCGA-CC-A8HT	LIHC	TCGA	RRQELARLR	DEG_APCC_DBOX_1	0.647
p.Q32H	DO52187	LIHC	ICGC	RRQELARLR	DEG_APCC_DBOX_1	0.647
p.E25D	TCGA-E6-A1M0	UCEC	TCGA	RRQELARLR	DEG_APCC_DBOX_1	0.1944
p.E25D	DO43682	UCEC	ICGC	RRQELARLR	DEG_APCC_DBOX_1	0.1944
p.E48K	TCGA-IR-A3LI	CESC	TCGA	RRQELARLR	DEG_APCC_DBOX_1	0.0556
p.E48K	DO44400	CESC	ICGC	RRQELARLR	DEG_APCC_DBOX_1	0.0556
p.R27Q	DO48368	BLCA	ICGC	RRQELARLR	DEG_APCC_DBOX_1	0.25
p.A35S	DO228948	LICA	ICGC	RRQELARLR	DEG_APCC_DBOX_1	0.6477
p.A35S	DO229042	LICA	ICGC	RRQELARLR	DEG_APCC_DBOX_1	0.6477
p.L34F	SIDM00683	Prostate Carcinoma	GDSC	RRQELARLR	DEG_APCC_DBOX_1	0.6981
p.L34F	ACH-000977	lymph_node	CCLE	RRQELARLR	DEG_APCC_DBOX_1	0.6981
p.L34F	LNCaP-Clone-FGC	prostate	COSMIC	RRQELARLR	DEG_APCC_DBOX_1	0.6981

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15696	U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2	DEG_APCC_DBOX_1	30:38	RRQELARLR	APC,CDC20,FZR1	0.8035	More...
Q15695	Putative U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 1	DEG_APCC_DBOX_1	36:44	RRQELARLR	APC,CDC20,FZR1	0.814	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons