DegronMD

Uniprot ID: E9PAV3

Source protein: Nascent polypeptide-associated complex subunit alpha, muscle-specific form

Source gene: NACA

Class: DEG_COP1_1

Location: 1890:1901

E3 ligase: COP1

DEGRON score: 0.9936

ASA_SCORE: 93.9

COIL: 0.9163

CONS_SCORE: 0.8823

DSS_SCORE: 0.8291

HELIX: 0.0691

FCONS_SCORE: 1.3134

RIG_SCORE: 0.6092

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N1885S	DO223286	UCEC	ICGC	TESDSDESVPEL	DEG_COP1_1	0.1944
p.T1882R	ACH-000802	Bladder Cancer	CCLE	TESDSDESVPEL	DEG_COP1_1	0.1111
p.T1882R	BFTC-905	urinary_tract	COSMIC	TESDSDESVPEL	DEG_COP1_1	0.1111
p.T1882M	ACH-002256	Leukemia	CCLE	TESDSDESVPEL	DEG_COP1_1	0.1111
p.T1882M	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	TESDSDESVPEL	DEG_COP1_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13765	Nascent polypeptide-associated complex subunit alpha	DEG_COP1_1	27:38	TESDSDESVPEL	COP1	0.9786	More...
E9PAV3	Nascent polypeptide-associated complex subunit alpha, muscle-specific form	DEG_COP1_1	1890:1901	TESDSDESVPEL	COP1	0.9936	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons