DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
TESDSDESVPEL
Uniprot ID:
Q13765
Source protein:
Nascent polypeptide-associated complex subunit alpha
Source gene:
NACA
Class:
DEG_COP1_1
Location:
27:38
E3 ligase:
COP1
DEGRON score:
0.9786
ASA_SCORE:
94.65
COIL:
0.8013
CONS_SCORE:
0.4758
DSS_SCORE:
0.9248
HELIX:
0.1826
FCONS_SCORE:
1.3072
RIG_SCORE:
0.595
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with NACA mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of TESDSDESVPEL
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q13765
Nascent polypeptide-associated complex subunit alpha
DEG_COP1_1
27:38
TESDSDESVPEL
COP1
0.9786
More...
E9PAV3
Nascent polypeptide-associated complex subunit alpha, muscle-specific form
DEG_COP1_1
1890:1901
TESDSDESVPEL
COP1
0.9936
More...