DegronMD

Uniprot ID: O95997

Source protein: Securin

Source gene: PTTG1

Class: DEG_APCC_DBOX_1

Location: 60:68

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9847

ASA_SCORE: 59.7889

COIL: 0.4116

CONS_SCORE: 0.8214

DSS_SCORE: 0.5844

HELIX: 0.4803

FCONS_SCORE: 1.594

RIG_SCORE: 0.7256

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R61K	TCGA-CW-5587	KIRC	TCGA	TRKALGTVN	DEG_APCC_DBOX_1	0.7237
p.R61K	DO19430	KIRC	ICGC	TRKALGTVN	DEG_APCC_DBOX_1	0.7237
p.S74Y	TCGA-XK-AAIW	PRAD	TCGA	TRKALGTVN	DEG_APCC_DBOX_1	0.1667
p.S74Y	DO51407	PRAD	ICGC	TRKALGTVN	DEG_APCC_DBOX_1	0.1667
p.T60N	DO224598	BRCA	ICGC	TRKALGTVN	DEG_APCC_DBOX_1	0.7055
p.T60N	DO1010	BRCA	ICGC	TRKALGTVN	DEG_APCC_DBOX_1	0.7055
p.F50I	SIDM00313	Hodgkin's Lymphoma	GDSC	TRKALGTVN	DEG_APCC_DBOX_1	0.0556
p.F50I	ACH-000702	Lymphoma	CCLE	TRKALGTVN	DEG_APCC_DBOX_1	0.0556
p.F50I	L-1236	haematopoietic_and_lymphoid_tissue	COSMIC	TRKALGTVN	DEG_APCC_DBOX_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95997	Securin	DEG_APCC_DBOX_1	60:68	TRKALGTVN	APC,CDC20,FZR1	0.9847	More...
Q9NZH5	Securin-2	DEG_APCC_DBOX_1	60:68	TRKALGTVN	APC,CDC20,FZR1	0.9798	More...
Q9NZH4	Putative pituitary tumor-transforming gene 3 protein	DEG_APCC_DBOX_1	60:68	TRKALGTVN	APC,CDC20,FZR1	0.9254	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons