DegronMD

Uniprot ID: Q9NZH5

Source protein: Securin-2

Source gene: PTTG2

Class: DEG_APCC_DBOX_1

Location: 60:68

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9798

ASA_SCORE: 59.7111

COIL: 0.3858

CONS_SCORE: 0.8039

DSS_SCORE: 0.5534

HELIX: 0.5526

FCONS_SCORE: 2.0251

RIG_SCORE: 0.7265

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A59T	TCGA-A5-A0G2	UCEC	TCGA	TRKALGTVN	DEG_APCC_DBOX_1	0.3056
p.A59T	DO41235	UCEC	ICGC	TRKALGTVN	DEG_APCC_DBOX_1	0.3056
p.A52V	DO23360	LINC	ICGC	TRKALGTVN	DEG_APCC_DBOX_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95997	Securin	DEG_APCC_DBOX_1	60:68	TRKALGTVN	APC,CDC20,FZR1	0.9847	More...
Q9NZH5	Securin-2	DEG_APCC_DBOX_1	60:68	TRKALGTVN	APC,CDC20,FZR1	0.9798	More...
Q9NZH4	Putative pituitary tumor-transforming gene 3 protein	DEG_APCC_DBOX_1	60:68	TRKALGTVN	APC,CDC20,FZR1	0.9254	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons