DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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Degron:
TRKALGTVN
Uniprot ID:
Q9NZH4
Source protein:
Putative pituitary tumor-transforming gene 3 protein
Source gene:
PTTG3P
Class:
DEG_APCC_DBOX_1
Location:
60:68
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.9254
ASA_SCORE:
56.1333
COIL:
0.3629
CONS_SCORE:
0.8134
DSS_SCORE:
0.5142
HELIX:
0.5542
FCONS_SCORE:
1.9126
RIG_SCORE:
0.7414
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with PTTG3P mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of TRKALGTVN
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O95997
Securin
DEG_APCC_DBOX_1
60:68
TRKALGTVN
APC,CDC20,FZR1
0.9847
More...
Q9NZH5
Securin-2
DEG_APCC_DBOX_1
60:68
TRKALGTVN
APC,CDC20,FZR1
0.9798
More...
Q9NZH4
Putative pituitary tumor-transforming gene 3 protein
DEG_APCC_DBOX_1
60:68
TRKALGTVN
APC,CDC20,FZR1
0.9254
More...