DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
VAIHQE
Uniprot ID:
P63136
Source protein:
Endogenous retrovirus group K member 25 Pol protein
Source gene:
ERVK-25
Class:
LIG_APCC_ABBA_1
Location:
894:899
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.6977
ASA_SCORE:
86.95
COIL:
0.545
CONS_SCORE:
0.2765
DSS_SCORE:
0.6076
HELIX:
0.1697
FCONS_SCORE:
1.1709
RIG_SCORE:
0.7673
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with ERVK-25 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of VAIHQE
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9BXR3
Endogenous retrovirus group K member 6 Pol protein
LIG_APCC_ABBA_1
896:901
VAIHQE
APC,CDC20,FZR1
0.7125
More...
P63133
Endogenous retrovirus group K member 8 Pol protein
LIG_APCC_ABBA_1
896:901
VAIHQE
APC,CDC20,FZR1
0.6059
More...
P63136
Endogenous retrovirus group K member 25 Pol protein
LIG_APCC_ABBA_1
894:899
VAIHQE
APC,CDC20,FZR1
0.6977
More...