DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
VAIHQE
Uniprot ID:
Q9BXR3
Source protein:
Endogenous retrovirus group K member 6 Pol protein
Source gene:
ERVK-6
Class:
LIG_APCC_ABBA_1
Location:
896:901
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.7125
ASA_SCORE:
88.9167
COIL:
0.57
CONS_SCORE:
0.2763
DSS_SCORE:
0.6012
HELIX:
0.3423
FCONS_SCORE:
1.2071
RIG_SCORE:
0.7688
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with ERVK-6 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of VAIHQE
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9BXR3
Endogenous retrovirus group K member 6 Pol protein
LIG_APCC_ABBA_1
896:901
VAIHQE
APC,CDC20,FZR1
0.7125
More...
P63133
Endogenous retrovirus group K member 8 Pol protein
LIG_APCC_ABBA_1
896:901
VAIHQE
APC,CDC20,FZR1
0.6059
More...
P63136
Endogenous retrovirus group K member 25 Pol protein
LIG_APCC_ABBA_1
894:899
VAIHQE
APC,CDC20,FZR1
0.6977
More...