DegronMD

Uniprot ID: Q8WXI7

Source protein: Mucin-16

Source gene: MUC16

Class: DEG_SCF_FBW7_1

Location: 10865:10871

E3 ligase: FBXW7

DEGRON score: 0.992

ASA_SCORE: 86.8286

COIL: 0.9381

CONS_SCORE: 0

DSS_SCORE: 0.5236

HELIX: 0.0079

FCONS_SCORE: 0

RIG_SCORE: 0.6685

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S10856C	TCGA-37-4132	LUSC	TCGA	VPTPTVS	DEG_SCF_FBW7_1	0.0833
p.S10856C	DO26528	LUSC	ICGC	VPTPTVS	DEG_SCF_FBW7_1	0.0833
p.G10858A	TCGA-94-A5I4	LUSC	TCGA	VPTPTVS	DEG_SCF_FBW7_1	0.1389
p.G10858A	DO219175	LUSC	ICGC	VPTPTVS	DEG_SCF_FBW7_1	0.1389
p.P10866L	TCGA-EE-A3J5	SKCM	TCGA	VPTPTVS	DEG_SCF_FBW7_1	0.6471
p.P10866L	DO47331	SKCM	ICGC	VPTPTVS	DEG_SCF_FBW7_1	0.6471
p.G10876R	TCGA-EE-A3JD	SKCM	TCGA	VPTPTVS	DEG_SCF_FBW7_1	0.1944
p.G10876R	DO50299	SKCM	ICGC	VPTPTVS	DEG_SCF_FBW7_1	0.1944
p.P10875Q	TCGA-GN-A26D	SKCM	TCGA	VPTPTVS	DEG_SCF_FBW7_1	0.2222
p.P10875Q	DO37480	SKCM	ICGC	VPTPTVS	DEG_SCF_FBW7_1	0.2222
p.P10866T	DO229018	LICA	ICGC	VPTPTVS	DEG_SCF_FBW7_1	0.5919
p.T10867N	DO229029	LICA	ICGC	VPTPTVS	DEG_SCF_FBW7_1	0.8166
p.V10874I	DO220898	MELA	ICGC	VPTPTVS	DEG_SCF_FBW7_1	0.25
p.P10866S	SIDM00752	Non-Cancerous	GDSC	VPTPTVS	DEG_SCF_FBW7_1	0.5641

DegronMD: protein-targeted degradation, mutation and drug response to degrons