DegronMD

Uniprot ID: Q8WXI7

Source protein: Mucin-16

Source gene: MUC16

Class: DEG_SCF_FBW7_1

Location: 11085:11091

E3 ligase: FBXW7

DEGRON score: 0.9922

ASA_SCORE: 84.9571

COIL: 0.9237

CONS_SCORE: 0

DSS_SCORE: 0.4995

HELIX: 0.0076

FCONS_SCORE: 0

RIG_SCORE: 0.6544

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T11089N	TCGA-06-0214	GBM	TCGA	VPTPTVS	DEG_SCF_FBW7_1	0.5944
p.T11089N	DO10960	GBM	ICGC	VPTPTVS	DEG_SCF_FBW7_1	0.5944
p.P11092H	TCGA-35-4123	LUAD	TCGA	VPTPTVS	DEG_SCF_FBW7_1	0.3056
p.P11092H	DO26394	LUAD	ICGC	VPTPTVS	DEG_SCF_FBW7_1	0.3056
p.H11077N	TCGA-86-8055	LUAD	TCGA	VPTPTVS	DEG_SCF_FBW7_1	0.1111
p.H11077N	DO25554	LUAD	ICGC	VPTPTVS	DEG_SCF_FBW7_1	0.1111
p.A11079V	TCGA-BR-7958	STAD	TCGA	VPTPTVS	DEG_SCF_FBW7_1	0.1667
p.A11079V	DO38344	STAD	ICGC	VPTPTVS	DEG_SCF_FBW7_1	0.1667
p.G11096E	TCGA-EE-A29L	SKCM	TCGA	VPTPTVS	DEG_SCF_FBW7_1	0.1944
p.G11096E	DO222599	MELA	ICGC	VPTPTVS	DEG_SCF_FBW7_1	0.1944
p.G11096E	DO37835	SKCM	ICGC	VPTPTVS	DEG_SCF_FBW7_1	0.1944
p.G11093R	TCGA-EE-A29V	SKCM	TCGA	VPTPTVS	DEG_SCF_FBW7_1	0.2778
p.G11093R	DO38006	SKCM	ICGC	VPTPTVS	DEG_SCF_FBW7_1	0.2778
p.G11093V	TCGA-EE-A2GT	SKCM	TCGA	VPTPTVS	DEG_SCF_FBW7_1	0.2778
p.G11093V	DO37946	SKCM	ICGC	VPTPTVS	DEG_SCF_FBW7_1	0.2778
p.S11091L	DO220851	MELA	ICGC	VPTPTVS	DEG_SCF_FBW7_1	0.8778
p.S11091L	DO47331	SKCM	ICGC	VPTPTVS	DEG_SCF_FBW7_1	0.8778

DegronMD: protein-targeted degradation, mutation and drug response to degrons