DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
VPTPTVS
Uniprot ID:
Q8WXI7
Source protein:
Mucin-16
Source gene:
MUC16
Class:
DEG_SCF_FBW7_1
Location:
11085:11091
E3 ligase:
FBXW7
DEGRON score:
0.9922
ASA_SCORE:
84.9571
COIL:
0.9237
CONS_SCORE:
0
DSS_SCORE:
0.4995
HELIX:
0.0076
FCONS_SCORE:
0
RIG_SCORE:
0.6544
Degron related mutations and impact score
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Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.S11091L
DO220851
MELA
ICGC
VPTPTVS
DEG_SCF_FBW7_1
0.8778
p.S11091L
DO47331
SKCM
ICGC
VPTPTVS
DEG_SCF_FBW7_1
0.8778
p.T11089N
TCGA-06-0214
GBM
TCGA
VPTPTVS
DEG_SCF_FBW7_1
0.5944
p.T11089N
DO10960
GBM
ICGC
VPTPTVS
DEG_SCF_FBW7_1
0.5944
p.P11092H
TCGA-35-4123
LUAD
TCGA
VPTPTVS
DEG_SCF_FBW7_1
0.3056
p.P11092H
DO26394
LUAD
ICGC
VPTPTVS
DEG_SCF_FBW7_1
0.3056
p.G11093R
TCGA-EE-A29V
SKCM
TCGA
VPTPTVS
DEG_SCF_FBW7_1
0.2778
p.G11093R
DO38006
SKCM
ICGC
VPTPTVS
DEG_SCF_FBW7_1
0.2778
p.G11093V
TCGA-EE-A2GT
SKCM
TCGA
VPTPTVS
DEG_SCF_FBW7_1
0.2778
p.G11093V
DO37946
SKCM
ICGC
VPTPTVS
DEG_SCF_FBW7_1
0.2778
p.G11096E
TCGA-EE-A29L
SKCM
TCGA
VPTPTVS
DEG_SCF_FBW7_1
0.1944
p.G11096E
DO222599
MELA
ICGC
VPTPTVS
DEG_SCF_FBW7_1
0.1944
p.G11096E
DO37835
SKCM
ICGC
VPTPTVS
DEG_SCF_FBW7_1
0.1944
p.A11079V
TCGA-BR-7958
STAD
TCGA
VPTPTVS
DEG_SCF_FBW7_1
0.1667
p.A11079V
DO38344
STAD
ICGC
VPTPTVS
DEG_SCF_FBW7_1
0.1667
p.H11077N
TCGA-86-8055
LUAD
TCGA
VPTPTVS
DEG_SCF_FBW7_1
0.1111
p.H11077N
DO25554
LUAD
ICGC
VPTPTVS
DEG_SCF_FBW7_1
0.1111
Showing 1 to 17 of 17 entries
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Drug responses associated with MUC16 mutations
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Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
No data available in table
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All proteins holding degron of VPTPTVS
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Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q8WXI7
Mucin-16
DEG_SCF_FBW7_1
10865:10871
VPTPTVS
FBXW7
0.992
More...
Q8WXI7
Mucin-16
DEG_SCF_FBW7_1
11085:11091
VPTPTVS
FBXW7
0.9922
More...
Showing 1 to 2 of 2 entries
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