DegronMD

Uniprot ID: Q685J3

Source protein: Mucin-17

Source gene: MUC17

Class: DEG_SCF_FBW7_1

Location: 1403:1410

E3 ligase: FBXW7

DEGRON score: 0.6566

ASA_SCORE: 90.3875

COIL: 0.9171

CONS_SCORE: 0.5236

DSS_SCORE: 0.5716

HELIX: 0.0146

FCONS_SCORE: 1

RIG_SCORE: 0.708

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1407L	TCGA-06-0650	GBM	TCGA	VSTTPVVS	DEG_SCF_FBW7_1	0.7582
p.P1407L	TCGA-A5-A0G2	UCEC	TCGA	VSTTPVVS	DEG_SCF_FBW7_1	0.7582
p.P1407L	DO12628	GBM	ICGC	VSTTPVVS	DEG_SCF_FBW7_1	0.7582
p.P1407L	DO41235	UCEC	ICGC	VSTTPVVS	DEG_SCF_FBW7_1	0.7582
p.P1397L	TCGA-06-2557	GBM	TCGA	VSTTPVVS	DEG_SCF_FBW7_1	0.1667
p.P1397L	TCGA-44-7662	LUAD	TCGA	VSTTPVVS	DEG_SCF_FBW7_1	0.1667
p.P1397L	TCGA-BR-6852	STAD	TCGA	VSTTPVVS	DEG_SCF_FBW7_1	0.1667
p.P1397L	TCGA-DB-A64L	LGG	TCGA	VSTTPVVS	DEG_SCF_FBW7_1	0.1667
p.P1397L	TCGA-EO-A22R	UCEC	TCGA	VSTTPVVS	DEG_SCF_FBW7_1	0.1667
p.P1397L	DO13318	GBM	ICGC	VSTTPVVS	DEG_SCF_FBW7_1	0.1667
p.P1397L	DO44615	LGG	ICGC	VSTTPVVS	DEG_SCF_FBW7_1	0.1667
p.P1397L	DO23597	LUAD	ICGC	VSTTPVVS	DEG_SCF_FBW7_1	0.1667
p.P1397L	DO38202	STAD	ICGC	VSTTPVVS	DEG_SCF_FBW7_1	0.1667
p.P1397L	DO42713	UCEC	ICGC	VSTTPVVS	DEG_SCF_FBW7_1	0.1667
p.P1397L	SIDM01146	Gastric Carcinoma	GDSC	VSTTPVVS	DEG_SCF_FBW7_1	0.1667
p.P1397L	SIDM01554	Mesothelioma	GDSC	VSTTPVVS	DEG_SCF_FBW7_1	0.1667
p.P1397L	NCI-SNU-1	stomach	COSMIC	VSTTPVVS	DEG_SCF_FBW7_1	0.1667
p.T1405S	TCGA-3C-AALI	BRCA	TCGA	VSTTPVVS	DEG_SCF_FBW7_1	0.6005
p.T1405S	DO219589	BRCA	ICGC	VSTTPVVS	DEG_SCF_FBW7_1	0.6005
p.S1410C	TCGA-85-A511	LUSC	TCGA	VSTTPVVS	DEG_SCF_FBW7_1	0.7541
p.S1410C	DO45509	LUSC	ICGC	VSTTPVVS	DEG_SCF_FBW7_1	0.7541
p.T1406M	TCGA-93-A4JN	LUAD	TCGA	VSTTPVVS	DEG_SCF_FBW7_1	0.7423
p.T1406M	DO218931	LUAD	ICGC	VSTTPVVS	DEG_SCF_FBW7_1	0.7423
p.T1406M	DO27833	MALY	ICGC	VSTTPVVS	DEG_SCF_FBW7_1	0.7423
p.S1414T	TCGA-95-7043	LUAD	TCGA	VSTTPVVS	DEG_SCF_FBW7_1	0.2222
p.S1414T	DO24739	LUAD	ICGC	VSTTPVVS	DEG_SCF_FBW7_1	0.2222
p.E1393K	TCGA-DA-A95Z	SKCM	TCGA	VSTTPVVS	DEG_SCF_FBW7_1	0.0556
p.E1393K	TCGA-FR-A8YE	SKCM	TCGA	VSTTPVVS	DEG_SCF_FBW7_1	0.0556
p.E1393K	DO229459	SKCA	ICGC	VSTTPVVS	DEG_SCF_FBW7_1	0.0556
p.E1393K	DO50303	SKCM	ICGC	VSTTPVVS	DEG_SCF_FBW7_1	0.0556
p.E1393K	DO219481	SKCM	ICGC	VSTTPVVS	DEG_SCF_FBW7_1	0.0556
p.G1394E	TCGA-EE-A181	SKCM	TCGA	VSTTPVVS	DEG_SCF_FBW7_1	0.0833
p.G1394E	TCGA-W3-A825	SKCM	TCGA	VSTTPVVS	DEG_SCF_FBW7_1	0.0833
p.G1394E	DO37444	SKCM	ICGC	VSTTPVVS	DEG_SCF_FBW7_1	0.0833
p.G1394E	DO51272	SKCM	ICGC	VSTTPVVS	DEG_SCF_FBW7_1	0.0833
p.E1393D	DO228299	LICA	ICGC	VSTTPVVS	DEG_SCF_FBW7_1	0.0556
p.T1395S	DO229057	LICA	ICGC	VSTTPVVS	DEG_SCF_FBW7_1	0.1111
p.T1395S	SIDM01180	Hepatocellular Carcinoma	GDSC	VSTTPVVS	DEG_SCF_FBW7_1	0.1111
p.T1395S	SNU-387	liver	COSMIC	VSTTPVVS	DEG_SCF_FBW7_1	0.1111
p.V1403D	SIDM00884	Breast Carcinoma	GDSC	VSTTPVVS	DEG_SCF_FBW7_1	0.7785
p.V1403D	SIDM01180	Hepatocellular Carcinoma	GDSC	VSTTPVVS	DEG_SCF_FBW7_1	0.7785
p.V1403D	SIDM01318	Hepatocellular Carcinoma	GDSC	VSTTPVVS	DEG_SCF_FBW7_1	0.7785
p.V1403D	SIDM01624	Bladder Carcinoma	GDSC	VSTTPVVS	DEG_SCF_FBW7_1	0.7785
p.V1403D	SIDM01689	B-Lymphoblastic Leukemia	GDSC	VSTTPVVS	DEG_SCF_FBW7_1	0.7785
p.V1403D	SIDM01598	Non-Small Cell Lung Carcinoma	GDSC	VSTTPVVS	DEG_SCF_FBW7_1	0.7785
p.V1403D	SIDM01758	B-Cell Non-Hodgkin's Lymphoma	GDSC	VSTTPVVS	DEG_SCF_FBW7_1	0.7785
p.V1403D	SIDM01677	Non-Small Cell Lung Carcinoma	GDSC	VSTTPVVS	DEG_SCF_FBW7_1	0.7785
p.I1401M	SIDM01180	Hepatocellular Carcinoma	GDSC	VSTTPVVS	DEG_SCF_FBW7_1	0.2778
p.I1401M	SIDM01598	Non-Small Cell Lung Carcinoma	GDSC	VSTTPVVS	DEG_SCF_FBW7_1	0.2778
p.I1401M	SNU-387	liver	COSMIC	VSTTPVVS	DEG_SCF_FBW7_1	0.2778
p.S1410N	SIDM00161	Biliary Tract Carcinoma	GDSC	VSTTPVVS	DEG_SCF_FBW7_1	0.7069
p.S1410N	ACH-000141	Gallbladder Cancer	CCLE	VSTTPVVS	DEG_SCF_FBW7_1	0.7069

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VSTTPVVS

Degron related mutations and impact score

Drug responses associated with MUC17 mutations

All proteins holding degron of VSTTPVVS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q685J3	Mucin-17	DEG_SCF_FBW7_1	1403:1410	VSTTPVVS	FBXW7	0.6566	More...
Q685J3	Mucin-17	DEG_SCF_FBW7_1	3406:3413	VSTTPVVS	FBXW7	0.7413	More...