DegronMD

Uniprot ID: Q685J3

Source protein: Mucin-17

Source gene: MUC17

Class: DEG_SCF_FBW7_1

Location: 3406:3413

E3 ligase: FBXW7

DEGRON score: 0.7413

ASA_SCORE: 84.6125

COIL: 0.8114

CONS_SCORE: 0.5236

DSS_SCORE: 0.5396

HELIX: 0.0153

FCONS_SCORE: 0.8857

RIG_SCORE: 0.7136

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S3403N	TCGA-AX-A0J1	UCEC	TCGA	VSTTPVVS	DEG_SCF_FBW7_1	0.25
p.S3403N	DO41199	UCEC	ICGC	VSTTPVVS	DEG_SCF_FBW7_1	0.25
p.P3423H	TCGA-D7-A4YV	STAD	TCGA	VSTTPVVS	DEG_SCF_FBW7_1	0.0556
p.P3423H	DO47777	STAD	ICGC	VSTTPVVS	DEG_SCF_FBW7_1	0.0556
p.T3409M	TCGA-DM-A28K	COAD	TCGA	VSTTPVVS	DEG_SCF_FBW7_1	0.7423
p.T3409M	TCGA-E9-A1NC	BRCA	TCGA	VSTTPVVS	DEG_SCF_FBW7_1	0.7423
p.T3409M	DO8167	COAD	ICGC	VSTTPVVS	DEG_SCF_FBW7_1	0.7423
p.T3409M	SIDM00052	Esophageal Squamous Cell Carcinoma	GDSC	VSTTPVVS	DEG_SCF_FBW7_1	0.7423
p.T3409M	HCE-4	oesophagus	COSMIC	VSTTPVVS	DEG_SCF_FBW7_1	0.7423
p.V3406I	TCGA-DU-6392	LGG	TCGA	VSTTPVVS	DEG_SCF_FBW7_1	0.5965
p.V3406I	DO22237	LGG	ICGC	VSTTPVVS	DEG_SCF_FBW7_1	0.5965
p.M3404V	TCGA-FI-A2D5	UCEC	TCGA	VSTTPVVS	DEG_SCF_FBW7_1	0.2778
p.M3404V	DO41331	UCEC	ICGC	VSTTPVVS	DEG_SCF_FBW7_1	0.2778
p.S3407N	TCGA-FI-A2D5	UCEC	TCGA	VSTTPVVS	DEG_SCF_FBW7_1	0.5958
p.S3407N	DO41331	UCEC	ICGC	VSTTPVVS	DEG_SCF_FBW7_1	0.5958
p.T3398S	TCGA-NC-A5HJ	LUSC	TCGA	VSTTPVVS	DEG_SCF_FBW7_1	0.1111
p.T3398S	DO219189	LUSC	ICGC	VSTTPVVS	DEG_SCF_FBW7_1	0.1111
p.T3421I	TCGA-WN-A9G9	KIRP	TCGA	VSTTPVVS	DEG_SCF_FBW7_1	0.1111
p.T3421I	DO51569	KIRP	ICGC	VSTTPVVS	DEG_SCF_FBW7_1	0.1111
p.V3416A	DO228944	LICA	ICGC	VSTTPVVS	DEG_SCF_FBW7_1	0.25
p.N3417S	DO228944	LICA	ICGC	VSTTPVVS	DEG_SCF_FBW7_1	0.2222
p.M3404I	DO228967	LICA	ICGC	VSTTPVVS	DEG_SCF_FBW7_1	0.2778
p.M3404I	DO229052	LICA	ICGC	VSTTPVVS	DEG_SCF_FBW7_1	0.2778
p.M3404I	DO229061	LICA	ICGC	VSTTPVVS	DEG_SCF_FBW7_1	0.2778
p.S3420L	DO222653	MELA	ICGC	VSTTPVVS	DEG_SCF_FBW7_1	0.1389
p.S3414Y	DO46588	OV	ICGC	VSTTPVVS	DEG_SCF_FBW7_1	0.3056
p.P3423S	DO218847	SKCA	ICGC	VSTTPVVS	DEG_SCF_FBW7_1	0.0556
p.P3410L	SIDM01113	Other Sarcomas	GDSC	VSTTPVVS	DEG_SCF_FBW7_1	0.7582
p.P3410L	SIDM00900	Non-Cancerous	GDSC	VSTTPVVS	DEG_SCF_FBW7_1	0.7582
p.P3410L	SIDM01608	Endometrial Carcinoma	GDSC	VSTTPVVS	DEG_SCF_FBW7_1	0.7582
p.P3410L	SIDM01316	Ewing's Sarcoma	GDSC	VSTTPVVS	DEG_SCF_FBW7_1	0.7582
p.V3416D	SIDM00870	Breast Carcinoma	GDSC	VSTTPVVS	DEG_SCF_FBW7_1	0.25
p.V3416D	ACH-000725	Breast Cancer	CCLE	VSTTPVVS	DEG_SCF_FBW7_1	0.25
p.V3416D	HCC202	breast	COSMIC	VSTTPVVS	DEG_SCF_FBW7_1	0.25
p.E3396K	ACH-001973	Metastasis	CCLE	VSTTPVVS	DEG_SCF_FBW7_1	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VSTTPVVS

Degron related mutations and impact score

Drug responses associated with MUC17 mutations

All proteins holding degron of VSTTPVVS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q685J3	Mucin-17	DEG_SCF_FBW7_1	1403:1410	VSTTPVVS	FBXW7	0.6566	More...
Q685J3	Mucin-17	DEG_SCF_FBW7_1	3406:3413	VSTTPVVS	FBXW7	0.7413	More...