DegronMD

Uniprot ID: Q8WXI7

Source protein: Mucin-16

Source gene: MUC16

Class: DEG_SCF_FBW7_1

Location: 10877:10883

E3 ligase: FBXW7

DEGRON score: 0.9449

ASA_SCORE: 91.3143

COIL: 0.8233

CONS_SCORE: 0

DSS_SCORE: 0.3908

HELIX: 0.0121

FCONS_SCORE: 0

RIG_SCORE: 0.805

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V10888L	TCGA-34-2596	LUSC	TCGA	VVTPLVT	DEG_SCF_FBW7_1	0.1944
p.V10888L	DO26508	LUSC	ICGC	VVTPLVT	DEG_SCF_FBW7_1	0.1944
p.P10880A	TCGA-91-6828	LUAD	TCGA	VVTPLVT	DEG_SCF_FBW7_1	0.7503
p.P10880A	DO26150	LUAD	ICGC	VVTPLVT	DEG_SCF_FBW7_1	0.7503
p.A10887T	TCGA-AP-A056	UCEC	TCGA	VVTPLVT	DEG_SCF_FBW7_1	0.2222
p.A10887T	DO43971	UCEC	ICGC	VVTPLVT	DEG_SCF_FBW7_1	0.2222
p.G10876R	TCGA-EE-A3JD	SKCM	TCGA	VVTPLVT	DEG_SCF_FBW7_1	0.3056
p.G10876R	DO50299	SKCM	ICGC	VVTPLVT	DEG_SCF_FBW7_1	0.3056
p.P10875Q	TCGA-GN-A26D	SKCM	TCGA	VVTPLVT	DEG_SCF_FBW7_1	0.2778
p.P10875Q	DO37480	SKCM	ICGC	VVTPLVT	DEG_SCF_FBW7_1	0.2778
p.S10885F	DO220875	MELA	ICGC	VVTPLVT	DEG_SCF_FBW7_1	0.2778
p.S10885F	DO222557	MELA	ICGC	VVTPLVT	DEG_SCF_FBW7_1	0.2778
p.S10885F	DO222880	MELA	ICGC	VVTPLVT	DEG_SCF_FBW7_1	0.2778
p.S10885F	SIDM01694	B-Lymphoblastic Leukemia	GDSC	VVTPLVT	DEG_SCF_FBW7_1	0.2778
p.S10885F	ACH-000728	Leukemia	CCLE	VVTPLVT	DEG_SCF_FBW7_1	0.2778
p.S10885L	DO220875	MELA	ICGC	VVTPLVT	DEG_SCF_FBW7_1	0.2778
p.P10880S	DO220877	MELA	ICGC	VVTPLVT	DEG_SCF_FBW7_1	0.6752
p.V10874I	DO220898	MELA	ICGC	VVTPLVT	DEG_SCF_FBW7_1	0.25
p.A10887E	SIDM00698	Small Cell Lung Carcinoma	GDSC	VVTPLVT	DEG_SCF_FBW7_1	0.2222
p.A10887E	ACH-000506	Lung Cancer	CCLE	VVTPLVT	DEG_SCF_FBW7_1	0.2222
p.A10887E	NCI-H146	lung	COSMIC	VVTPLVT	DEG_SCF_FBW7_1	0.2222
p.S10885Y	SIDM00193	Colorectal Carcinoma	GDSC	VVTPLVT	DEG_SCF_FBW7_1	0.2778
p.S10885Y	ACH-000991	Colon/Colorectal Cancer	CCLE	VVTPLVT	DEG_SCF_FBW7_1	0.2778
p.S10885Y	SNU-81	large_intestine	COSMIC	VVTPLVT	DEG_SCF_FBW7_1	0.2778
p.T10879P	SIDM00863	Burkitt's Lymphoma	GDSC	VVTPLVT	DEG_SCF_FBW7_1	0.7031
p.T10879P	ACH-001064	Lymphoma	CCLE	VVTPLVT	DEG_SCF_FBW7_1	0.7031
p.T10879P	EB2	haematopoietic_and_lymphoid_tissue	COSMIC	VVTPLVT	DEG_SCF_FBW7_1	0.7031

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VVTPLVT

Degron related mutations and impact score

Drug responses associated with MUC16 mutations

All proteins holding degron of VVTPLVT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WXI7	Mucin-16	DEG_SCF_FBW7_1	10877:10883	VVTPLVT	FBXW7	0.9449	More...
Q8WXI7	Mucin-16	DEG_SCF_FBW7_1	11097:11103	VVTPLVT	FBXW7	0.9558	More...