DegronMD

Uniprot ID: Q8WXI7

Source protein: Mucin-16

Source gene: MUC16

Class: DEG_SCF_FBW7_1

Location: 11097:11103

E3 ligase: FBXW7

DEGRON score: 0.9558

ASA_SCORE: 89.9429

COIL: 0.8229

CONS_SCORE: 0

DSS_SCORE: 0.4078

HELIX: 0.0119

FCONS_SCORE: 0

RIG_SCORE: 0.7792

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P11092H	TCGA-35-4123	LUAD	TCGA	VVTPLVT	DEG_SCF_FBW7_1	0.1944
p.P11092H	DO26394	LUAD	ICGC	VVTPLVT	DEG_SCF_FBW7_1	0.1944
p.T11103N	TCGA-CC-A1HT	LIHC	TCGA	VVTPLVT	DEG_SCF_FBW7_1	0.7055
p.T11103N	DO23028	LIHC	ICGC	VVTPLVT	DEG_SCF_FBW7_1	0.7055
p.T11103P	TCGA-CC-A1HT	LIHC	TCGA	VVTPLVT	DEG_SCF_FBW7_1	0.7031
p.T11103P	DO23028	LIHC	ICGC	VVTPLVT	DEG_SCF_FBW7_1	0.7031
p.R11106S	TCGA-D3-A1Q3	SKCM	TCGA	VVTPLVT	DEG_SCF_FBW7_1	0.25
p.R11106S	DO47509	SKCM	ICGC	VVTPLVT	DEG_SCF_FBW7_1	0.25
p.G11096E	TCGA-EE-A29L	SKCM	TCGA	VVTPLVT	DEG_SCF_FBW7_1	0.3056
p.G11096E	DO222599	MELA	ICGC	VVTPLVT	DEG_SCF_FBW7_1	0.3056
p.G11096E	DO37835	SKCM	ICGC	VVTPLVT	DEG_SCF_FBW7_1	0.3056
p.G11093R	TCGA-EE-A29V	SKCM	TCGA	VVTPLVT	DEG_SCF_FBW7_1	0.2222
p.G11093R	DO38006	SKCM	ICGC	VVTPLVT	DEG_SCF_FBW7_1	0.2222
p.G11093V	TCGA-EE-A2GT	SKCM	TCGA	VVTPLVT	DEG_SCF_FBW7_1	0.2222
p.G11093V	DO37946	SKCM	ICGC	VVTPLVT	DEG_SCF_FBW7_1	0.2222
p.S11105F	TCGA-WE-A8K4	SKCM	TCGA	VVTPLVT	DEG_SCF_FBW7_1	0.2778
p.S11105F	DO51281	SKCM	ICGC	VVTPLVT	DEG_SCF_FBW7_1	0.2778
p.S11104N	DO222990	BTCA	ICGC	VVTPLVT	DEG_SCF_FBW7_1	0.3056
p.S11104N	DO229010	COCA	ICGC	VVTPLVT	DEG_SCF_FBW7_1	0.3056
p.S11104N	DO229016	COCA	ICGC	VVTPLVT	DEG_SCF_FBW7_1	0.3056
p.S11104N	DO229005	COCA	ICGC	VVTPLVT	DEG_SCF_FBW7_1	0.3056
p.S11104N	DO228957	LICA	ICGC	VVTPLVT	DEG_SCF_FBW7_1	0.3056
p.S11104N	DO230542	LUSC	ICGC	VVTPLVT	DEG_SCF_FBW7_1	0.3056
p.S11104N	DO52365	LUSC	ICGC	VVTPLVT	DEG_SCF_FBW7_1	0.3056
p.V11097M	DO227999	COCA	ICGC	VVTPLVT	DEG_SCF_FBW7_1	0.6097
p.V11097M	DO229003	COCA	ICGC	VVTPLVT	DEG_SCF_FBW7_1	0.6097
p.V11097M	DO229005	COCA	ICGC	VVTPLVT	DEG_SCF_FBW7_1	0.6097
p.V11097M	DO229505	LAML	ICGC	VVTPLVT	DEG_SCF_FBW7_1	0.6097

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WXI7	Mucin-16	DEG_SCF_FBW7_1	10877:10883	VVTPLVT	FBXW7	0.9449	More...
Q8WXI7	Mucin-16	DEG_SCF_FBW7_1	11097:11103	VVTPLVT	FBXW7	0.9558	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VVTPLVT

Degron related mutations and impact score

Drug responses associated with MUC16 mutations

All proteins holding degron of VVTPLVT